Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPIHLS)

Drug Name
Diclofenac Drug Info
Synonyms Diclofenac (sodium matrix patch, pain)
Therapeutic ClassNeurology Agents
Cross-matching ID
PubChem CID
3033
ChEBI ID
CHEMBL139
CAS Number
CAS 15307-86-5
TTD Drug ID
D0TG1H
VARIDT Drug ID
DR00681
INTEDE Drug ID
DR0488
ACDINA Drug ID
D00192

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.12 0.00e+0 34/36 (94.44%) RFC5;MCM2;PRIM1;...
Progesterone-mediated oocyte maturation 1.91 2.16e-2 75/100 (75%) PLK1;CCNA2;STK10;...
PPAR signaling pathway 1.85 2.88e-2 66/74 (89.19%) FABP4;CD36;ACSL5;...
Cell cycle 1.78 4.59e-2 110/124 (88.71%) CDC20;CDC45;PLK1;...
Spliceosome 1.77 4.32e-2 101/150 (67.33%) LSM5;HNRNPM;SNRPD1;...
Ribosome biogenesis in eukaryotes 1.76 4.14e-2 52/108 (48.15%) DKC1;PWP2;NOP56;...
Fat digestion and absorption 1.74 4.32e-2 35/43 (81.4%) CD36;FABP1;ACAT2;...
Mitophagy -2.00 0.00e+0 56/68 (82.35%) MRAS;SRC;CALCOCO2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H