Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPJKRL)

Drug Name
BITHIONOL Drug Info
Synonyms
bithionol; 97-18-7; Actamer; Bithin; 2,2'-Thiobis(4,6-dichlorophenol); Lorothidol; Bitionol; Bithionol sulfide; Bisoxyphen; Bidiphen; Lorothiodol; Bitin; Nobacter; Bithionolate; Neopellis; Vancide BL; Usaf B-22; Bithional; Bithionolum; 2-Hydroxy-3,5-dichlorophenyl sulfide; TKhsd; Bis(2-hydroxy-3,5-dichlorophenyl) sulfide; Bis(3,5-dichloro-2-hydroxyphenyl) sulfide; 2,2'-sulfanediylbis(4,6-dichlorophenol); Caswell No. 852; Bitionol [INN-Spanish]; XL 7; Bithionolum [INN-Latin]; 2,2'-Dihydroxy-3,3',5,5'-tetrachlorodiphenyl sulfide
Cross-matching ID
PubChem CID
2406
ChEBI ID
CHEMBL290106
CAS Number
CAS 97-18-7
TTD Drug ID
D0QQ1J
VARIDT Drug ID
DR00936

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.09 1.11e-2 127/171 (74.27%) HERPUD1;DDIT3;ATF4;...
TNF signaling pathway 1.87 4.45e-2 103/112 (91.96%) ATF4;CXCL3;CXCL5;...
Mitophagy 1.85 3.34e-2 56/68 (82.35%) ATF4;SQSTM1;CSNK2B;...
Glycine, serine and threonine metabolism 1.85 2.50e-2 31/40 (77.5%) PHGDH;CBS;PSAT1;...
Amino sugar and nucleotide sugar metabolism 1.80 2.22e-2 38/48 (79.17%) GFPT1;GMDS;HK2;...
Rheumatoid arthritis 1.77 3.15e-2 78/93 (83.87%) VEGFA;CXCL3;CXCL8;...
NF-kappa B signaling pathway 1.77 2.70e-2 90/104 (86.54%) GADD45A;RELB;CXCL3;...
Oocyte meiosis -1.73 3.41e-2 90/129 (69.77%) CDC23;AR;CUL1;...
Fatty acid degradation -1.74 3.39e-2 40/43 (93.02%) ACSL1;ACSBG1;ACOX1;...
Cell cycle -1.77 2.12e-2 110/124 (88.71%) CDC14B;CUL1;DBF4;...
Homologous recombination -1.85 1.33e-2 35/41 (85.37%) BLM;POLD2;RAD51D;...
Drug metabolism -1.85 1.77e-2 78/151 (51.66%) GSTM1;GSTM2;CYP3A4;...
Mismatch repair -1.91 1.77e-2 22/23 (95.65%) RFC4;POLD1;MSH2;...
DNA replication -2.50 0.00e+0 34/36 (94.44%) RFC4;RNASEH2A;POLD1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H