General Information of Drug (ID: DMPKI0N)

Drug Name
EBIO Drug Info
Synonyms
10045-45-1; 1-Ethyl-2-benzimidazolinone; 1-EBIO; 1-ethyl-1H-benzo[d]imidazol-2(3H)-one; 1-Ethylbenzimidazolinone; 1-Ethylbenzimidazolin-2-one; 1-ethyl-1,3-dihydro-2h-benzimidazol-2-one; 2H-Benzimidazol-2-one, 1-ethyl-1,3-dihydro-; 1-Ethyl-Benzimidazolinone; UNII-M82W79SS4W; 3-ethyl-1H-benzimidazol-2-one; EINECS 233-148-1; CHEMBL452887; M82W79SS4W; CHEBI:34076; CXUCKELNYMZTRT-UHFFFAOYSA-N; 1-ethyl-2,3-dihydro-1H-1,3-benzodiazol-2-one; 1-EB10; EBIO; 1-ethyl-1,3-dihydrobenzimidazol-2-one; Tocris-1041; AC1Q2ZX3; AC1Q2ZX4
Cross-matching ID
PubChem CID
82320
ChEBI ID
CHEMBL452887
CAS Number
CAS 10045-45-1
TTD Drug ID
D0T0AG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Vibrio cholerae infection 2.43 0.00e+0 44/50 (88%) PRKACA;ATP6AP1;PDIA4;...
Oxidative phosphorylation 2.41 0.00e+0 93/133 (69.92%) ATP6AP1;COX5B;NDUFS8;...
Synaptic vesicle cycle 2.21 0.00e+0 63/78 (80.77%) AP2S1;ATP6V0E2;AP2M1;...
Phagosome 2.08 0.00e+0 118/152 (77.63%) TFRC;ATP6AP1;ATP6V0E2;...
Glycine, serine and threonine metabolism 2.06 0.00e+0 31/40 (77.5%) MAOA;CTH;MAOB;...
Collecting duct acid secretion 2.04 0.00e+0 22/27 (81.48%) ATP6V0E2;ATP6V1A;ATP6V1G1;...
Citrate cycle (TCA cycle) 2.00 0.00e+0 30/30 (100%) PCK1;IDH2;IDH1;...
Lysosome 2.00 0.00e+0 115/128 (89.84%) CTSD;NPC2;SORT1;...
Cardiac muscle contraction 1.99 0.00e+0 64/87 (73.56%) TNNC1;COX5B;ATP1A1;...
Histidine metabolism 1.95 1.17e-3 16/22 (72.73%) MAOA;MAOB;ALDH2;...
Valine, leucine and isoleucine degradation 1.94 1.07e-3 42/48 (87.5%) ALDH6A1;ALDH2;MCCC1;...
Thyroid hormone synthesis 1.92 9.78e-4 66/75 (88%) GPX3;PRKACA;PRKCB;...
Fatty acid degradation 1.89 1.81e-3 40/43 (93.02%) ECI2;ALDH2;ACAA1;...
Arginine and proline metabolism 1.87 1.68e-3 39/50 (78%) MAOA;MAOB;ALDH2;...
Glutathione metabolism 1.84 4.70e-3 43/57 (75.44%) GPX3;GSTM3;GSTM2;...
Diabetic cardiomyopathy 1.81 5.14e-3 162/203 (79.8%) CTSD;PRKCB;MPC1;...
Protein export 1.79 4.83e-3 17/23 (73.91%) SRP14;HSPA5;SEC61A1;...
Parkinson disease 1.77 5.87e-3 176/249 (70.68%) PRKACA;MAOA;GNAI2;...
Cocaine addiction 1.76 6.80e-3 42/49 (85.71%) PRKACA;MAOA;GNAI2;...
Thermogenesis 1.76 7.63e-3 173/232 (74.57%) RPS6KA2;PRKACA;COX5B;...
Amphetamine addiction 1.75 8.95e-3 57/69 (82.61%) PRKACA;MAOA;PRKCB;...
Endocrine and other factor-regulated calcium reabsorpti... 1.75 8.54e-3 49/53 (92.45%) PRKACA;PRKCB;AP2S1;...
Antigen processing and presentation 1.71 1.74e-2 60/78 (76.92%) IFI30;LGMN;CANX;...
Pyruvate metabolism 1.70 1.96e-2 41/47 (87.23%) PCK1;AKR1A1;ALDH2;...
Protein processing in endoplasmic reticulum 1.69 1.88e-2 127/171 (74.27%) PDIA4;DNAJB1;SSR4;...
SNARE interactions in vesicular transport 1.69 1.85e-2 19/33 (57.58%) VAMP1;STX1A;SNAP29;...
Cholesterol metabolism 1.69 1.91e-2 44/50 (88%) NPC2;SORT1;STAR;...
Sulfur metabolism 1.66 2.26e-2 9/10 (90%) PAPSS2;TST;PAPSS1;...
Endocytosis 1.65 2.51e-2 198/252 (78.57%) TFRC;PDGFRA;RAB11FIP1;...
Ascorbate and aldarate metabolism 1.65 2.47e-2 15/30 (50%) AKR1A1;ALDH2;ALDH7A1;...
Pyrimidine metabolism -2.08 8.12e-3 40/56 (71.43%) TK2;DCTD;ENTPD4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H