Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPMYE8)

Drug Name
Miconazole Drug Info
Synonyms
Dactarin; MCZ; Miconazol; Miconazolo; Miconazolum; Micozole; Minostate; Monistat; Vusion; Zimycan; Daktarin IV; Miconasil Nitrate; Miconazole nitrate salt; Miconazolo [DCIT]; Monistat IV; MJR 1762; Miconazole 3; Miconazole 3 Combination Pack; Miconazole 7 Combination Pack; Monazole 7; Monistat 1 Combination Pack; Monistat 3 Vaginal Ovules; Monistat 5 Tampon; Monistat 7 Vaginal Suppositories; R 18134; Aflorix(nitrate); Albistat(nitrate); Andergin(nitrate); Conofite(nitrate); Daktarin (TN); Femizol (TN); Femizol-M; Florid(nitrate); Lotrimin AF(nitrate); Micantin (nitrate); Micatin (TN); Miconazex (TN); Miconazol [INN-Spanish]; Miconazole-7; Miconazolum [INN-Latin]; Monista (nitrate); Monistat (TN); Monistat 3 Dual-Pak; Monistat 7 Dual-Pak; Monistat Dual-PAK; Monistat iv (TN); Monistat-Derm; Novo-Miconazole Vaginal Ovules; Epi-Monistat(nitrate); Gyno-Daktar(nitrate); Monistat-Derm (TN); R-14,889; Miconazole (JP15/USP/INN); Miconazole [USAN:BAN:INN:JAN]; Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)-(9CI); Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-(9CI); (+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole; 1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole; 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole; 1-[2,4-Dichloro-beta-([2,4-dichloro-benzyl]oxy)phenethyl]imidazole; 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole; 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole; 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole; 1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole; 1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
Therapeutic ClassAntifungal Agents
Cross-matching ID
PubChem CID
4189
ChEBI ID
CHEMBL91
CAS Number
CAS 22916-47-8
TTD Drug ID
D00AXJ
VARIDT Drug ID
DR00477
INTEDE Drug ID
DR1084
ACDINA Drug ID
D00429

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Amino sugar and nucleotide sugar metabolism 2.16 0.00e+0 38/48 (79.17%) GPI;HK2;AMDHD2;...
Intestinal immune network for IgA production 2.10 0.00e+0 38/48 (79.17%) CXCL12;HLA-DPB1;HLA-DPA1;...
Glycolysis / Gluconeogenesis 2.05 6.74e-3 56/67 (83.58%) FBP1;PFKL;GPI;...
Glutathione metabolism 2.02 5.05e-3 43/57 (75.44%) GPX3;IDH2;GSTA1;...
Fructose and mannose metabolism 2.02 4.04e-3 30/33 (90.91%) AKR1B1;AKR1B10;FBP1;...
Cysteine and methionine metabolism 1.98 3.37e-3 43/50 (86%) BHMT2;ADI1;GOT1;...
Pentose and glucuronate interconversions 1.91 5.77e-3 17/34 (50%) AKR1B1;AKR1B10;UGP2;...
Pentose phosphate pathway 1.90 6.31e-3 25/30 (83.33%) FBP1;PFKL;GPI;...
Pyruvate metabolism 1.84 1.57e-2 41/47 (87.23%) ACAT2;MDH1;ADH5;...
Tryptophan metabolism 1.84 1.41e-2 35/42 (83.33%) KYNU;AOC1;ACAT2;...
Ferroptosis 1.83 1.56e-2 36/41 (87.8%) ACSL1;TF;ATG7;...
Fatty acid elongation 1.81 1.68e-2 19/27 (70.37%) ELOVL2;ACOT7;TECR;...
Folate biosynthesis 1.78 2.02e-2 23/26 (88.46%) AKR1C3;AKR1B1;AKR1B10;...
NF-kappa B signaling pathway 1.77 2.17e-2 90/104 (86.54%) CXCL12;IRAK1;LYN;...
Galactose metabolism 1.76 2.09e-2 26/31 (83.87%) AKR1B1;AKR1B10;PFKL;...
Rheumatoid arthritis 1.70 3.16e-2 78/93 (83.87%) CXCL12;HLA-DPB1;HLA-DPA1;...
Pyrimidine metabolism 1.70 3.09e-2 40/56 (71.43%) DCK;NME4;CAD;...
RNA polymerase 1.68 3.59e-2 23/31 (74.19%) POLR2I;POLR2L;POLR3K;...
Glycerolipid metabolism 1.68 3.40e-2 44/61 (72.13%) MGLL;AKR1B1;PLPP3;...
Proximal tubule bicarbonate reclamation 1.68 3.49e-2 21/23 (91.3%) SLC4A4;MDH1;CA2;...
Arginine and proline metabolism 1.67 3.42e-2 39/50 (78%) AOC1;GOT1;GATM;...
PPAR signaling pathway 1.67 3.26e-2 66/74 (89.19%) SCD;FABP7;ACSL1;...
Citrate cycle (TCA cycle) 1.67 3.12e-2 30/30 (100%) IDH2;MDH1;PCK2;...
Asthma 1.63 4.93e-2 25/31 (80.65%) HLA-DPB1;HLA-DPA1;HLA-DQA1;...
Sulfur metabolism 1.63 4.97e-2 9/10 (90%) PAPSS2;TST;MPST
Tuberculosis 1.62 4.98e-2 159/180 (88.33%) HLA-DPB1;CTSS;IRAK1;...
Terpenoid backbone biosynthesis 1.61 4.95e-2 18/22 (81.82%) ACAT2;ACAT1;IDI1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 8uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H