Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPP4DT)

Drug Name
Trimethobenzamide Drug Info
Synonyms Tigan; Trimethobenzamide Hydrochloride; Trimethobenzamide Hydrochloride Preservative Free
Cross-matching ID
PubChem CID
5577
ChEBI ID
CHEMBL27796
CAS Number
CAS 138-56-7
TTD Drug ID
D0A8FB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Autoimmune thyroid disease 2.21 0.00e+0 46/53 (86.79%) CD40;HLA-DQB1;CD86;...
Asthma 2.18 0.00e+0 25/31 (80.65%) CD40;HLA-DQB1;FCER1A;...
Viral protein interaction with cytokine and cytokine re... 2.12 3.69e-3 84/100 (84%) CXCL2;CXCL11;CCL4;...
Allograft rejection 2.11 2.77e-3 32/38 (84.21%) CD40;HLA-DQB1;CD86;...
Intestinal immune network for IgA production 2.09 2.21e-3 38/48 (79.17%) CD40;HLA-DQB1;CD86;...
Type I diabetes mellitus 2.02 1.84e-3 38/43 (88.37%) HLA-DQB1;CD86;HLA-DQA1;...
Systemic lupus erythematosus 1.96 1.58e-3 45/135 (33.33%) CD40;C1QA;HLA-DQB1;...
Rheumatoid arthritis 1.96 1.38e-3 78/93 (83.87%) CXCL2;CXCL6;CXCL5;...
Th17 cell differentiation 1.94 3.69e-3 95/107 (88.79%) PRKCQ;HLA-DQB1;IL27RA;...
Viral myocarditis 1.90 3.32e-3 53/60 (88.33%) CD40;HLA-DQB1;CD86;...
Toxoplasmosis 1.90 4.02e-3 103/112 (91.96%) CD40;BAD;HSPA8;...
Cell adhesion molecules 1.88 4.61e-3 118/148 (79.73%) CD40;HLA-DQB1;NCAM1;...
Legionellosis 1.84 6.81e-3 51/57 (89.47%) CXCL2;HSPA8;NAIP;...
Primary immunodeficiency 1.84 6.32e-3 33/38 (86.84%) CD40;IL2RG;CD3D;...
Chemokine signaling pathway 1.84 5.90e-3 163/192 (84.9%) CXCL2;BAD;CXCL11;...
Toll-like receptor signaling pathway 1.82 6.92e-3 94/104 (90.38%) CD40;CXCL11;CCL4;...
NF-kappa B signaling pathway 1.79 1.11e-2 90/104 (86.54%) CD40;CXCL2;PRKCQ;...
Th1 and Th2 cell differentiation 1.76 1.48e-2 80/92 (86.96%) PRKCQ;HLA-DQB1;HLA-DQA1;...
Leishmaniasis 1.76 1.40e-2 67/77 (87.01%) HLA-DQB1;HLA-DQA1;IFNGR1;...
Inflammatory bowel disease 1.73 2.10e-2 58/65 (89.23%) HLA-DQB1;HLA-DQA1;IFNGR1;...
Graft-versus-host disease 1.72 2.06e-2 32/42 (76.19%) HLA-DQB1;CD86;HLA-DQA1;...
Cytokine-cytokine receptor interaction 1.72 2.21e-2 246/295 (83.39%) CD40;CXCL2;CXCL11;...
Antigen processing and presentation 1.70 2.21e-2 60/78 (76.92%) CREB1;HSPA8;HLA-DQB1;...
Hematopoietic cell lineage 1.64 4.33e-2 90/99 (90.91%) HLA-DQB1;HLA-DQA1;HLA-DPB1;...
Basal cell carcinoma -1.88 1.80e-2 41/63 (65.08%) FZD3;DVL1;TCF7L1;...
Mineral absorption -2.06 0.00e+0 48/60 (80%) HMOX1;SLC34A2;SLC5A1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 2.22uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 2.22uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 2.22uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 2.22uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 2.22uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H