Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPQSE4)

Drug Name
HCV-796 Drug Info
Synonyms Nesbuvir; Nesbuvir (USAN); 79Z
Cross-matching ID
PubChem CID
11561383
CAS Number
CAS 691852-58-1
TTD Drug ID
D05DDN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Pentose and glucuronate interconversions -1.73 4.84e-2 17/34 (50%) AKR1A1;DCXR;AKR1B10;...
NF-kappa B signaling pathway -1.73 4.99e-2 90/104 (86.54%) VCAM1;CD40LG;DDX58;...
Intestinal immune network for IgA production -1.77 3.38e-2 38/48 (79.17%) TGFB1;HLA-DOA;CCR10;...
Necroptosis -1.80 2.95e-2 113/159 (71.07%) BCL2;SLC25A6;IFNG;...
Rheumatoid arthritis -1.81 2.84e-2 78/93 (83.87%) TNFSF13;CD28;ATP6V1A;...
Retinol metabolism -1.83 3.25e-2 41/68 (60.29%) CYP2A6;CYP3A7;ADH1B;...
Type I diabetes mellitus -1.92 1.97e-2 38/43 (88.37%) HLA-E;HLA-A;INS;...
Metabolism of xenobiotics by cytochrome P450 -1.95 1.77e-2 49/77 (63.64%) CYP2A6;EPHX1;SULT2A1;...
Mineral absorption -2.14 0.00e+0 48/60 (80%) MT1M;ATP2B1;FTL;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H