Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPTMKH)

Drug Name
KN-93 Drug Info
Synonyms
kn-93; 139298-40-1; KN 93; KN93; Methoxybenzene-sulfonamide; C26H29ClN2O4S; CHEMBL155333; (E)-N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide; 2-(N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl))amino-N-(4-chlorocinnamyl)-N-methylbenzylamine; N-(2-(((3-(4-Chlorophenyl)-2-propenyl)methylamino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide; Benzenesulfonamide, N-(2-(((3-(4-chlorophenyl)-2-propenyl)methylamino)methyl)ph
Cross-matching ID
PubChem CID
5312122
ChEBI ID
CHEMBL91460
CAS Number
CAS 139298-40-1
TTD Drug ID
D0XT3Z

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.67 0.00e+0 19/20 (95%) MSMO1;DHCR24;DHCR7;...
Lysosome 2.07 0.00e+0 115/128 (89.84%) GM2A;NPC2;NEU1;...
Terpenoid backbone biosynthesis 2.01 0.00e+0 18/22 (81.82%) HMGCS1;IDI1;HMGCR;...
Protein export -1.80 1.07e-2 17/23 (73.91%) HSPA5;SEC63;SEC61G;...
Spliceosome -1.81 9.97e-3 101/150 (67.33%) SRSF1;SNRPE;DHX15;...
Proximal tubule bicarbonate reclamation -1.82 1.07e-2 21/23 (91.3%) SLC25A10;ATP1A2;AQP1;...
Ribosome biogenesis in eukaryotes -1.85 4.75e-3 52/108 (48.15%) TBL3;FBL;GTPBP4;...
RNA transport -1.86 3.56e-3 128/186 (68.82%) NUP50;NUP188;SEC13;...
Cell cycle -1.94 0.00e+0 110/124 (88.71%) RB1;CDKN2B;MCM3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.12uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.12uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.12uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.12uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.12uM - 10uM 6H