Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPU2WX)

Drug Name
Omacetaxine mepesuccinate Drug Info
Synonyms Synribo (TN)
Cross-matching ID
PubChem CID
285033
ChEBI ID
CHEMBL71019
CAS Number
CAS 26833-87-4
TTD Drug ID
D0M4XY
ACDINA Drug ID
D01298

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
NF-kappa B signaling pathway 2.15 0.00e+0 90/104 (86.54%) NFKBIA;RELB;TNFAIP3;...
RIG-I-like receptor signaling pathway 2.05 0.00e+0 64/70 (91.43%) NFKBIA;NFKBIB;CXCL10;...
Proteasome 2.01 0.00e+0 44/46 (95.65%) PSME4;PSMB1;PSMD6;...
IL-17 signaling pathway 2.00 1.91e-3 84/94 (89.36%) NFKBIA;TNFAIP3;JUN;...
TNF signaling pathway 1.99 1.53e-3 103/112 (91.96%) NFKBIA;TNFAIP3;JUN;...
Ribosome biogenesis in eukaryotes 1.98 1.27e-3 52/108 (48.15%) EIF6;RPP38;REXO5;...
Basal transcription factors 1.90 3.28e-3 37/45 (82.22%) MNAT1;CCNH;TAF2;...
Cytosolic DNA-sensing pathway 1.82 8.60e-3 52/63 (82.54%) NFKBIA;NFKBIB;CXCL10;...
C-type lectin receptor signaling pathway 1.78 1.44e-2 93/104 (89.42%) NFKBIA;RELB;JUN;...
Ribosome 1.77 1.30e-2 113/158 (71.52%) MRPS18A;MRPL23;RPL26L1;...
Viral protein interaction with cytokine and cytokine re... 1.76 1.46e-2 84/100 (84%) CXCL2;CCL19;CXCL10;...
Spliceosome 1.72 2.10e-2 101/150 (67.33%) PPIE;PRPF3;NCBP1;...
Coronavirus disease 1.71 2.12e-2 215/232 (92.67%) NFKBIA;JUN;C3;...
mRNA surveillance pathway 1.70 2.08e-2 71/98 (72.45%) GSPT2;PCF11;CSTF3;...
Inflammatory bowel disease 1.68 2.45e-2 58/65 (89.23%) JUN;NFKB1;TGFB2;...
Epstein-Barr virus infection 1.67 2.49e-2 189/202 (93.56%) NFKBIA;RELB;TNFAIP3;...
Circadian rhythm 1.66 2.79e-2 26/31 (83.87%) PER2;PER1;CRY1;...
Th17 cell differentiation 1.62 4.08e-2 95/107 (88.79%) NFKBIA;JUN;NFKBIB;...
NOD-like receptor signaling pathway 1.59 4.75e-2 145/181 (80.11%) NFKBIA;TNFAIP3;JUN;...
Leishmaniasis 1.58 4.86e-2 67/77 (87.01%) NFKBIA;JUN;C3;...
Vibrio cholerae infection -1.66 4.99e-2 44/50 (88%) ATP6V1B1;ADCY9;ATP6V1C1;...
Aldosterone-regulated sodium reabsorption -1.67 4.78e-2 34/37 (91.89%) PIK3R3;PIK3CB;INS;...
Fc gamma R-mediated phagocytosis -1.68 4.54e-2 79/97 (81.44%) PLD1;MYO10;PIK3R3;...
Proximal tubule bicarbonate reclamation -1.68 4.86e-2 21/23 (91.3%) SLC25A10;ATP1B1;ATP1B2;...
Glycosaminoglycan biosynthesis -1.76 2.48e-2 40/58 (68.97%) HS6ST1;CHST1;EXTL3;...
DNA replication -1.78 1.89e-2 34/36 (94.44%) POLA1;RFC5;RNASEH2A;...
Mineral absorption -1.82 9.77e-3 48/60 (80%) ATP1B1;ATP1B2;MT1X;...
Antigen processing and presentation -1.83 9.55e-3 60/78 (76.92%) HLA-DPA1;HLA-F;HLA-DRA;...
Biosynthesis of unsaturated fatty acids -1.89 6.63e-3 21/27 (77.78%) HSD17B4;HACD2;HSD17B12;...
Glycosphingolipid biosynthesis -1.90 5.97e-3 37/57 (64.91%) ST6GALNAC4;B4GALT2;HEXA;...
Sphingolipid metabolism -1.90 6.82e-3 32/49 (65.31%) CERS2;SPTLC1;CERK;...
Various types of N-glycan biosynthesis -1.93 7.96e-3 26/39 (66.67%) ALG3;MAN2A2;MAN2A1;...
Mucin type O-glycan biosynthesis -1.97 2.39e-3 20/36 (55.56%) ST6GALNAC4;GALNT14;GALNT6;...
Glycosaminoglycan degradation -1.98 2.99e-3 19/19 (100%) HEXA;HPSE;IDS;...
Protein processing in endoplasmic reticulum -2.07 0.00e+0 127/171 (74.27%) EIF2AK3;VCP;CRYAB;...
Steroid biosynthesis -2.42 0.00e+0 19/20 (95%) TM7SF2;SC5D;LSS;...
Lysosome -2.74 0.00e+0 115/128 (89.84%) CTSC;ACP5;HEXA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.03uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 3.33uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 3.33uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 1.11uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 1.11uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 1.11uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 1.11uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 1.11uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 1.11uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 2.5uM - 10uM 6H, 24H
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 1.11uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 10uM 6H, 24H, 48H
NCI-H1437 CVCL_1472 Homo sapiens 1.11uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 1.11uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 1.11uM 24H
HCC1588 CVCL_1263 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 1.11uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 0.12uM - 1.11uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 1.11uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 1.11uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 0.74uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 1.11uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 1.11uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 1.11uM 24H