Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPUIWD)

• Drug Name: Viloxazine Drug Info
• Synonyms: Viloxazine hydrochloride; 35604-67-2; 2-((2-Ethoxyphenoxy)methyl)morpholine hydrochloride; Vivalan; Vicilan; Emovit; Viloxazine HCl; 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride; CCRIS 1915; Viloxazine hydrochloride [USAN]; Viloxacina clorhidrato [Spanish]; EINECS 252-638-6; ICI 58,834; 2-((2-ethoxyphenoxy)methyl)morpholinehydrochloride; 2-((o-Ethoxyphenoxy)methyl)morpholine hydrochloride; 2-(2-Ethoxyphenoxymethyl)tetrahydro-1,4-oxazine hydrochloride; 2-(2-Ethoxyphenoxymethyl)-2,3,5,6-tetrahydro-1,4-oxazine hydrochl
• Cross-matching ID:
  PubChem CID: 5666
  ChEBI ID: CHEMBL306700
  CAS Number: CAS 46817-91-8
  TTD Drug ID: D0V9JR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Complement and coagulation cascades	2.38	0.00e+0	76/85 (89.41%)	C3;FGG;SERPINA1;...
Staphylococcus aureus infection	2.10	0.00e+0	72/95 (75.79%)	C3;FGG;CFD;...
Parkinson disease	1.99	2.72e-3	176/249 (70.68%)	TUBB2A;COX7A1;ATP5MC1;...
PPAR signaling pathway	1.98	2.04e-3	66/74 (89.19%)	FABP5;FABP4;HMGCS2;...
Prion disease	1.96	3.26e-3	209/273 (76.56%)	TUBB2A;CAV2;COX7A1;...
DNA replication	1.91	8.15e-3	34/36 (94.44%)	PCNA;RPA3;RFC2;...
Diabetic cardiomyopathy	1.90	6.98e-3	162/203 (79.8%)	COX7A1;ATP5MC1;AKT1;...
Huntington disease	1.87	1.02e-2	233/306 (76.14%)	GPX2;TUBB2A;COX7A1;...
Oxidative phosphorylation	1.86	1.18e-2	93/133 (69.92%)	COX7A1;ATP5MC1;ATP5MF;...
Tyrosine metabolism	1.81	1.87e-2	30/36 (83.33%)	ADH1B;ALDH3A1;AOC3;...
Pyrimidine metabolism	1.76	2.59e-2	40/56 (71.43%)	RRM2;TYMP;CANT1;...
Mismatch repair	1.75	2.58e-2	22/23 (95.65%)	PCNA;RPA3;RFC2;...
Folate biosynthesis	1.71	3.32e-2	23/26 (88.46%)	AKR1C3;AKR1B10;MOCOS;...
Arachidonic acid metabolism	1.68	3.96e-2	48/61 (78.69%)	GPX2;AKR1C3;CBR3;...
Drug metabolism	1.68	3.69e-2	78/151 (51.66%)	ADH1B;ALDH3A1;RRM2;...
Amyotrophic lateral sclerosis	1.65	4.79e-2	267/364 (73.35%)	GPX2;ANG;TUBB2A;...
Pertussis	1.65	4.60e-2	64/76 (84.21%)	C3;C1R;SERPING1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲