Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPWBNU)

• Drug Name: L-755507 Drug Info
• Synonyms: 159182-43-1; L755507; L-755,507; CHEMBL12998; 4-[[(HEXYLAMINO)CARBONYL]AMINO]-N-[4-[2-[[(2S)-2-HYDROXY-3-(4-HYDROXYPHENOXY)PROPYL]AMINO]ETHYL]PHENYL]-BENZENESULFONAMIDE; L 755507; SCHEMBL5165122; GTPL3931; MolPort-003-983-607; ZINC3939153; EX-A2397; s7974; BDBM50070156; AKOS024456983; CP-0074; CS-7782; NCGC00092331-01; HY-19334; F10055; L755507, > J-009574; L-755 507; (S)-4-(3-hexylureido)-N-(4-(2-(1-hydroxy-2-(4-hydroxyphenoxy)ethylamino)ethyl)phenyl)benzenesulfonamide
• Cross-matching ID:
  PubChem CID: 9829836
  ChEBI ID: CHEMBL12998
  CAS Number: CAS 159182-43-1
  TTD Drug ID: D04YJU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.39	0.00e+0	19/20 (95%)	MSMO1;DHCR24;DHCR7;...
Legionellosis	2.04	1.26e-2	51/57 (89.47%)	CYCS;C3;PYCARD;...
Terpenoid backbone biosynthesis	1.98	1.26e-2	18/22 (81.82%)	HMGCS1;IDI1;HMGCR;...
Biosynthesis of unsaturated fatty acids	1.89	1.26e-2	21/27 (77.78%)	SCD;FADS2;FADS1;...
Pertussis	1.83	2.01e-2	64/76 (84.21%)	C3;PYCARD;CD14;...
Pathogenic Escherichia coli infection	1.82	2.30e-2	152/197 (77.16%)	CLDN7;CYCS;MYO5C;...
C-type lectin receptor signaling pathway	1.82	1.97e-2	93/104 (89.42%)	PYCARD;PPP3CA;SRC;...
Leishmaniasis	1.78	2.83e-2	67/77 (87.01%)	MARCKSL1;C3;CYBA;...
Tuberculosis	1.74	3.21e-2	159/180 (88.33%)	CYCS;C3;PPP3CA;...
PD-L1 expression and PD-1 checkpoint pathway in cancer	1.74	2.89e-2	79/89 (88.76%)	CD3D;PPP3CA;MYD88;...
Neutrophil extracellular trap formation	1.72	3.42e-2	101/189 (53.44%)	FGG;C3;PLCB1;...
Proximal tubule bicarbonate reclamation	-1.87	3.43e-2	21/23 (91.3%)	ATP1B3;CA4;FXYD2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼