Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPY6IG)

Drug Name
QUIPAZINE Drug Info
Synonyms
quipazine; 4774-24-7; 2-(piperazin-1-yl)quinoline; 2-Piperazin-1-yl-quinoline; 2-Piperazin-1-ylquinoline; Quinoline, 2-(1-piperazinyl)-; 2-(1-Piperazinyl)quinoline; Quipazine [INN]; 1-(2-Quinolinyl)piperazine; Quipazinum [INN-Latin]; Quipazina [INN-Spanish]; UNII-4WCY05C0SJ; 1-(2-Quinolyl)piperazine; 2-(1-Piperazinyl)chinolin; BRN 0196945; 4WCY05C0SJ; CHEMBL18772; 2-quinolylpiperazine; F3306-0004; Quipazinum; Quipazina; TPC-A004; MA-1291; Spectrum_001733; Tocris-0629; piperazin-1-yl-quinoline; AC1L1JEX; AC1Q4WAV; Spectrum4_001259
Cross-matching ID
PubChem CID
5011
ChEBI ID
CHEMBL18772
CAS Number
CAS 4774-24-7
TTD Drug ID
D08BCF
VARIDT Drug ID
DR00969

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Asthma 2.04 0.00e+0 25/31 (80.65%) FCER1A;HLA-DPA1;HLA-DOB;...
Tyrosine metabolism 1.97 3.97e-3 30/36 (83.33%) ADH1B;ADH1C;TYRP1;...
Drug metabolism 1.93 7.94e-3 78/151 (51.66%) ADH1B;ADH1C;DUT;...
Systemic lupus erythematosus 1.92 5.96e-3 45/135 (33.33%) C7;HLA-DPA1;C3;...
Oxidative phosphorylation 1.90 6.35e-3 93/133 (69.92%) ATP5MC3;COX5A;PPA2;...
Staphylococcus aureus infection 1.88 5.29e-3 72/95 (75.79%) DEFB1;HLA-DPA1;C3;...
Metabolism of xenobiotics by cytochrome P450 1.87 7.94e-3 49/77 (63.64%) ADH1B;ADH1C;UGT2B15;...
p53 signaling pathway 1.83 9.93e-3 63/73 (86.3%) CCNB2;THBS1;CCND2;...
Intestinal immune network for IgA production 1.81 1.06e-2 38/48 (79.17%) HLA-DPA1;ITGA4;HLA-DOB;...
Ribosome 1.74 1.91e-2 113/158 (71.52%) MRPS7;MRPL15;MRPS2;...
Glycine, serine and threonine metabolism -1.96 6.13e-3 31/40 (77.5%) GLDC;PGAM1;CTH;...
TNF signaling pathway -1.98 0.00e+0 103/112 (91.96%) TAB2;AKT3;CASP3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H