Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPYQ7B)

• Drug Name: Trimebutine Drug Info
• Synonyms: Trimebutine maleate; Trimedat; Dromostat; Ibutin; Digerent polifarma; EINECS 251-845-9; TM 906; (1-Ethyl-1-phenyl-2-(3,4,5-trimethoxybenzoyloxy)ethyl)dimethylammonium hydrogen maleate; AC1O5HFA; Benzoic acid, 3,4,5-trimethoxy-, beta-(dimethylamino)-beta-ethylphenethyl ester, maleate (1:1); 34140-59-5; SCHEMBL1652810; C22H29NO5.C4H4O4; AKOS026750056; LS-38470; dimethyl-[2-phenyl-1-(3,4,5-trimethoxybenzoyl)oxybutan-2-yl]azanium; (E)-4-hydroxy-4-oxobut-2-enoate; Benzoic acid, 3,4,5-trimethoxy-, beta-(dimethylamino)-beta-ethyl
• Cross-matching ID:
  PubChem CID: 5573
  ChEBI ID: CHEMBL190044
  CAS Number: CAS 58997-89-0
  TTD Drug ID: D0E0CT
  INTEDE Drug ID: DR1646

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Cell cycle	1.90	1.79e-2	110/124 (88.71%)	PCNA;SMC1A;CDKN1B;...
Ribosome	-1.64	4.91e-2	113/158 (71.52%)	RPL13A;RPS21;RPS3A;...
Systemic lupus erythematosus	-1.66	4.21e-2	45/135 (33.33%)	C9;CD40LG;IL10;...
Parkinson disease	-1.67	3.81e-2	176/249 (70.68%)	COX8A;ATP5PO;CYCS;...
Complement and coagulation cascades	-1.73	2.47e-2	76/85 (89.41%)	F2;CPB2;C1S;...
NF-kappa B signaling pathway	-1.78	1.10e-2	90/104 (86.54%)	CXCL2;PLAU;LTA;...
Ferroptosis	-1.87	1.57e-3	36/41 (87.8%)	GCLM;NCOA4;ATG5;...
Vibrio cholerae infection	-1.88	1.69e-3	44/50 (88%)	SEC61G;ATP6V0C;CFTR;...
Histidine metabolism	-1.88	1.83e-3	16/22 (72.73%)	MAOA;MAOB;AOC1;...
Oxidative phosphorylation	-1.91	9.98e-4	93/133 (69.92%)	ATP6V0E2;NDUFS4;ATP6V1B2;...
Rheumatoid arthritis	-1.92	1.10e-3	78/93 (83.87%)	ATP6V1B1;CTLA4;CD86;...
Autoimmune thyroid disease	-1.93	1.22e-3	46/53 (86.79%)	CTLA4;CD86;CD28;...
Retinol metabolism	-2.04	0.00e+0	41/68 (60.29%)	ADH5;CYP3A7;UGT2B17;...
Type I diabetes mellitus	-2.04	0.00e+0	38/43 (88.37%)	CD86;CD28;PRF1;...
Antigen processing and presentation	-2.05	0.00e+0	60/78 (76.92%)	HLA-DOA;HSPA8;CD8B;...
IL-17 signaling pathway	-2.07	0.00e+0	84/94 (89.36%)	CASP3;HSP90AB1;TRAF6;...
Metabolism of xenobiotics by cytochrome P450	-2.14	0.00e+0	49/77 (63.64%)	CYP2A13;CYP2C9;ADH6;...
Allograft rejection	-2.17	0.00e+0	32/38 (84.21%)	CD86;CD28;PRF1;...
Mineral absorption	-2.32	0.00e+0	48/60 (80%)	STEAP1;ATP1B3;ATP1B2;...
Graft-versus-host disease	-2.38	0.00e+0	32/42 (76.19%)	CD86;CD28;PRF1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼