Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMPZFDE)

Drug Name
CASTANOSPERMINE Drug Info
Synonyms MDL-26190; (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyoctahydroindolizine
Cross-matching ID
PubChem CID
54445
ChEBI ID
CHEMBL311226
CAS Number
CAS 79831-76-8
TTD Drug ID
D09NYB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.63 0.00e+0 113/158 (71.52%) RPS5;RPL35A;RPL13;...
Oxidative phosphorylation 2.59 0.00e+0 93/133 (69.92%) ATP5F1C;ATP5MC3;ATP5MC2;...
Parkinson disease 2.50 0.00e+0 176/249 (70.68%) UCHL1;ATP5F1C;ATP5MC3;...
Huntington disease 2.32 0.00e+0 233/306 (76.14%) GPX1;ATP5F1C;ATP5MC3;...
Proteasome 2.30 0.00e+0 44/46 (95.65%) PSMD14;PSMB3;PSMB1;...
Prion disease 2.09 0.00e+0 209/273 (76.56%) HSPA8;PIK3R3;ATP5F1C;...
Allograft rejection 2.08 0.00e+0 32/38 (84.21%) HLA-DRA;HLA-DPB1;HLA-DPA1;...
Amyotrophic lateral sclerosis 2.06 0.00e+0 267/364 (73.35%) GPX1;ATP5F1C;ATP5MC3;...
Diabetic cardiomyopathy 2.05 1.18e-3 162/203 (79.8%) PIK3R3;ATP5F1C;MMP9;...
Thiamine metabolism 2.04 1.06e-3 12/15 (80%) AK1;AK4;ALPL;...
DNA replication 2.00 9.68e-4 34/36 (94.44%) RPA3;SSBP1;PCNA;...
Nucleotide excision repair 1.98 8.87e-4 40/47 (85.11%) MNAT1;RPA3;PCNA;...
Autoimmune thyroid disease 1.98 8.19e-4 46/53 (86.79%) HLA-DRA;HLA-DPB1;HLA-DPA1;...
Antigen processing and presentation 1.97 7.60e-4 60/78 (76.92%) HLA-DRA;HSPA8;HLA-DPB1;...
Mismatch repair 1.93 2.13e-3 22/23 (95.65%) RPA3;SSBP1;PCNA;...
Glycolysis / Gluconeogenesis 1.84 6.65e-3 56/67 (83.58%) PFKL;GPI;GAPDH;...
Asthma 1.84 6.26e-3 25/31 (80.65%) HLA-DRA;HLA-DPB1;HLA-DPA1;...
Type I diabetes mellitus 1.83 7.10e-3 38/43 (88.37%) HLA-DRA;HLA-DPB1;HLA-DPA1;...
Graft-versus-host disease 1.80 1.01e-2 32/42 (76.19%) HLA-DRA;HLA-DPB1;HLA-DPA1;...
Alzheimer disease 1.78 1.28e-2 279/369 (75.61%) PIK3R3;ATP5F1C;ATP5MC3;...
Pathways of neurodegeneration 1.78 1.22e-2 354/475 (74.53%) GPX1;UCHL1;ATP5F1C;...
Ferroptosis 1.77 1.16e-2 36/41 (87.8%) PCBP2;TF;ACSL3;...
Thermogenesis 1.76 1.30e-2 173/232 (74.57%) ATP5F1C;ATP5MC3;ATP5MC2;...
Non-alcoholic fatty liver disease 1.75 1.42e-2 126/155 (81.29%) CXCL8;PIK3R3;COX6B1;...
Pentose and glucuronate interconversions 1.72 1.75e-2 17/34 (50%) CRYL1;SORD;AKR1A1;...
Phosphonate and phosphinate metabolism 1.72 1.68e-2 5/6 (83.33%) CHPT1
Vibrio cholerae infection 1.70 1.85e-2 44/50 (88%) KDELR3;GNAS;ATP6V1F;...
Retrograde endocannabinoid signaling 1.69 2.02e-2 118/148 (79.73%) GRIA2;GNG11;NDUFB5;...
Protein export 1.69 2.02e-2 17/23 (73.91%) SRPRB;SEC61G;SPCS1;...
Epstein-Barr virus infection 1.68 1.96e-2 189/202 (93.56%) E2F2;HLA-DRA;PIK3R3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H