General Information of Drug (ID: DMPZS7U)

Drug Name
Oxyphenbutazone Drug Info
Synonyms Tandearil
Cross-matching ID
PubChem CID
4641
ChEBI ID
CHEMBL1228
CAS Number
CAS 129-20-4
TTD Drug ID
D06ZPS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Porphyrin and chlorophyll metabolism 2.15 0.00e+0 23/43 (53.49%) HMOX1;BLVRB;CP;...
Mineral absorption 2.14 0.00e+0 48/60 (80%) HMOX1;FTH1;MT1G;...
Legionellosis 2.07 0.00e+0 51/57 (89.47%) HSPA1A;HSPA6;HSPA8;...
Protein processing in endoplasmic reticulum 2.03 0.00e+0 127/171 (74.27%) HSPA1A;HSPA6;DNAJB1;...
Fluid shear stress and atherosclerosis 1.88 5.70e-3 123/139 (88.49%) HMOX1;SQSTM1;NQO1;...
Complement and coagulation cascades 1.86 7.92e-3 76/85 (89.41%) SERPINB2;C4BPA;C1QA;...
Antigen processing and presentation 1.83 6.79e-3 60/78 (76.92%) HSPA1A;HSPA6;HSPA8;...
Mitophagy 1.75 2.97e-2 56/68 (82.35%) SQSTM1;CITED2;TAX1BP1;...
IL-17 signaling pathway 1.74 3.17e-2 84/94 (89.36%) S100A9;CEBPB;CXCL8;...
Lipid and atherosclerosis 1.72 3.90e-2 190/215 (88.37%) HSPA1A;HSPA6;HSPA8;...
Ferroptosis 1.72 3.97e-2 36/41 (87.8%) HMOX1;FTH1;SLC3A2;...
HIF-1 signaling pathway 1.71 4.20e-2 105/109 (96.33%) HMOX1;CDKN1A;IGF1R;...
Pertussis 1.71 3.95e-2 64/76 (84.21%) CXCL8;C4BPA;C1QA;...
Staphylococcus aureus infection 1.70 3.67e-2 72/95 (75.79%) C1QA;DEFB1;C1QB;...
Metabolism of xenobiotics by cytochrome P450 1.69 3.74e-2 49/77 (63.64%) CYP1B1;AKR1C1;GSTM3;...
Systemic lupus erythematosus 1.67 4.40e-2 45/135 (33.33%) CTSG;ELANE;C1QA;...
MAPK signaling pathway 1.66 4.47e-2 272/294 (92.52%) HSPA1A;HSPA6;HSPB1;...
Glycine, serine and threonine metabolism 1.64 4.96e-2 31/40 (77.5%) PHGDH;GATM;CBS;...
MicroRNAs in cancer 1.64 4.75e-2 146/310 (47.1%) HMOX1;DDIT4;SPRY2;...
Diabetic cardiomyopathy -1.80 3.41e-2 162/203 (79.8%) NCF2;ATP5F1E;NDUFB11;...
DNA replication -1.81 3.85e-2 34/36 (94.44%) POLE2;POLA1;MCM4;...
Mismatch repair -1.85 2.62e-2 22/23 (95.65%) MSH2;POLD2;LIG1;...
Citrate cycle (TCA cycle) -2.05 0.00e+0 30/30 (100%) IDH3A;DLD;ACO1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H