Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQ1Q37)

Drug Name
Megesterol acetate Drug Info
Cross-matching ID
PubChem CID
11683
TTD Drug ID
D02IRD

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.08 0.00e+0 19/20 (95%) SQLE;DHCR24;SC5D;...
Biosynthesis of unsaturated fatty acids 1.91 2.74e-2 21/27 (77.78%) HACD2;SCD;ELOVL5;...
Other types of O-glycan biosynthesis 1.90 2.19e-2 29/47 (61.7%) ST6GAL1;GALNT1;GALNT2;...
PPAR signaling pathway 1.88 2.19e-2 66/74 (89.19%) ACSL1;HMGCS1;SCD;...
Estrogen signaling pathway 1.86 2.19e-2 119/137 (86.86%) KRT14;KRT15;KRT13;...
Retinol metabolism 1.86 2.01e-2 41/68 (60.29%) UGT2B28;HSD17B6;CYP3A7;...
Staphylococcus aureus infection 1.82 2.66e-2 72/95 (75.79%) KRT14;KRT15;KRT13;...
N-Glycan biosynthesis 1.80 2.74e-2 38/50 (76%) ST6GAL1;ALG6;ALG8;...
Bacterial invasion of epithelial cells 1.78 3.53e-2 59/77 (76.62%) FN1;PXN;ITGA5;...
Fatty acid biosynthesis 1.76 3.62e-2 16/18 (88.89%) ACSL1;FASN;ACACA;...
Complement and coagulation cascades 1.74 3.49e-2 76/85 (89.41%) FGG;FGB;F5;...
TGF-beta signaling pathway -1.82 3.86e-2 81/94 (86.17%) TGFB2;FMOD;HAMP;...
Viral protein interaction with cytokine and cytokine re... -1.84 4.90e-2 84/100 (84%) CCL19;CCR2;CCR5;...
Ribosome -1.94 1.78e-2 113/158 (71.52%) RPS18;RPS11;RPL9;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 12uM - 100uM 48H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 12uM - 100uM 48H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H