Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQ2FKJ)

Drug Name	Teriflunomide Drug Info
Cross-matching ID	PubChem CID 54684141 ChEBI ID CHEMBL973 CAS Number CAS 163451-81-8 TTD Drug ID D07QFP VARIDT Drug ID DR00092 ACDINA Drug ID D00665

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.04	1.14e-2	34/36 (94.44%)	RPA3;MCM3;MCM5;...
Spliceosome	1.88	2.28e-2	101/150 (67.33%)	PUF60;SRSF7;HNRNPA1;...
IL-17 signaling pathway	1.88	1.52e-2	84/94 (89.36%)	CXCL2;S100A8;CXCL1;...
Rheumatoid arthritis	1.81	3.98e-2	78/93 (83.87%)	CXCL2;CXCL1;CXCL3;...
Ribosome	-1.96	0.00e+0	113/158 (71.52%)	RPL7A;RPL34;RPL27;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	1.25uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H