Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQ63J2)

Drug Name
EM-101 Drug Info
Synonyms EM-100 series; LY-3; LY-303511; MTOR pathway inhibitors (cancer), Emiliem; MTOR pathway inhibitors (cancer), NIH
Cross-matching ID
PubChem CID
3971
ChEBI ID
CHEMBL1363184
CAS Number
CAS 154447-38-8
TTD Drug ID
D09VHS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Platelet activation 1.81 4.63e-2 106/124 (85.48%) PLA2G4A;ADCY9;PPP1CC;...
Notch signaling pathway 1.80 4.42e-2 49/59 (83.05%) TLE4;NOTCH1;JAG2;...
Autophagy 1.78 4.04e-2 113/169 (66.86%) PDPK1;RRAGC;ATG2A;...
beta-Alanine metabolism -1.60 4.99e-2 25/30 (83.33%) CNDP2;ECHS1;ACOX3;...
Pertussis -1.63 4.36e-2 64/76 (84.21%) CASP1;CD14;CASP7;...
Ascorbate and aldarate metabolism -1.67 2.54e-2 15/30 (50%) AKR1A1;UGDH;KL;...
Ribosome biogenesis in eukaryotes -1.69 2.30e-2 52/108 (48.15%) NAT10;DKC1;MPHOSPH10;...
Fructose and mannose metabolism -1.69 2.21e-2 30/33 (90.91%) PFKFB3;ALDOB;PMM1;...
Glycine, serine and threonine metabolism -1.70 2.01e-2 31/40 (77.5%) SARDH;PSPH;PSAT1;...
Protein export -1.70 2.14e-2 17/23 (73.91%) SEC63;SRPRA;SEC62;...
Tyrosine metabolism -1.71 2.28e-2 30/36 (83.33%) DBH;TH;TAT;...
Retinol metabolism -1.71 2.33e-2 41/68 (60.29%) CYP2A6;RETSAT;ADH1A;...
Steroid hormone biosynthesis -1.72 2.45e-2 43/61 (70.49%) UGT2B4;CYP11B1;CYP17A1;...
Protein processing in endoplasmic reticulum -1.73 2.39e-2 127/171 (74.27%) CRYAA;RRBP1;HSP90B1;...
Metabolism of xenobiotics by cytochrome P450 -1.79 1.23e-2 49/77 (63.64%) UGT2B4;HPGDS;GSTA3;...
Phenylalanine metabolism -1.80 1.11e-2 14/17 (82.35%) GOT2;MIF;DDC;...
Arginine and proline metabolism -1.80 1.24e-2 39/50 (78%) GOT2;PYCR3;CNDP2;...
Primary bile acid biosynthesis -1.80 1.39e-2 15/17 (88.24%) CYP27A1;ACOX2;CYP7A1;...
Pentose and glucuronate interconversions -1.81 1.36e-2 17/34 (50%) RPE;AKR1A1;UGDH;...
Glutathione metabolism -1.84 1.06e-2 43/57 (75.44%) GSTP1;IDH2;MGST2;...
Peroxisome -1.86 1.11e-2 72/82 (87.8%) PEX3;ACOX2;DDO;...
Histidine metabolism -1.87 1.39e-2 16/22 (72.73%) FTCD;CNDP2;HAL;...
Folate biosynthesis -1.89 1.06e-2 23/26 (88.46%) FPGS;CBR1;MOCS2;...
Complement and coagulation cascades -1.99 3.98e-3 76/85 (89.41%) CFHR4;CFH;F2;...
Drug metabolism -1.99 7.95e-3 78/151 (51.66%) UGT2B4;HPGDS;FMO4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.66uM - 10uM 6H, 24H