Details of the Drug Pharmacogenomic Perturbation Atlas

Camostat Drug Info

Camostat; 59721-28-7; camostate; Camostat [INN]; Camostatum [INN-Latin]; UNII-0FD207WKDU; CCRIS 7219; 4-(2-(2-(Dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate; 0FD207WKDU; C20H22N4O5; Camostat (INN); Foipan; FOY 305; FOY-305; Dimethylcarbamoylmethyl 4-(4-guqnidinobenzoyloxy)phenylacetat; foypan; Camostatum; CHEMBL85164; camostate-mesilate; [4-[2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl] 4-(diaminomethylideneamino)benzoate; p-Guanidinobenzoic acid, ester with (p-hydroxyphenyl)acetic acid, ester with N

Cross-matching ID

PubChem CID

2536

ChEBI ID

CHEMBL590799

CAS Number

CAS 59721-28-7

TTD Drug ID

D0Y6SQ

VARIDT Drug ID

DR00883

General Information of Drug (ID: DMQ7UL8)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Growth hormone synthesis, secretion and action	2.11	0.00e+0	108/119 (90.76%)	SHC1;CREB1;ADCY7;...
MicroRNAs in cancer	1.97	2.12e-2	146/310 (47.1%)	SHC1;CYP1B1;SLC7A1;...
Glioma	1.92	1.88e-2	67/75 (89.33%)	SHC1;TGFA;AKT1;...
Small cell lung cancer	1.90	1.77e-2	90/92 (97.83%)	LAMA4;COL4A2;LAMB1;...
Platelet activation	1.82	3.67e-2	106/124 (85.48%)	ADCY7;GNAS;ADCY1;...
Insulin resistance	1.81	3.30e-2	96/108 (88.89%)	CREB1;PRKCQ;MLXIP;...
Melanogenesis	1.81	3.03e-2	74/101 (73.27%)	CREB1;LEF1;ADCY7;...
Primary immunodeficiency	1.80	3.18e-2	33/38 (86.84%)	RFX5;IL7R;CD79A;...
Relaxin signaling pathway	1.72	4.94e-2	114/129 (88.37%)	SHC1;CREB1;COL4A2;...
Cholinergic synapse	1.71	4.80e-2	99/113 (87.61%)	CREB1;ADCY7;GNG11;...
Insulin secretion	1.71	4.59e-2	75/86 (87.21%)	CREB1;ADCY7;GNAS;...
Inflammatory mediator regulation of TRP channels	1.71	4.57e-2	82/98 (83.67%)	PRKCQ;ADCY7;GNAS;...
Amoebiasis	1.70	4.63e-2	99/102 (97.06%)	LAMA4;COL4A2;LAMB1;...
Biosynthesis of unsaturated fatty acids	1.69	4.39e-2	21/27 (77.78%)	FADS1;SCD;FADS2;...
Non-small cell lung cancer	1.69	4.17e-2	70/72 (97.22%)	TGFA;STAT3;AKT1;...
Human T-cell leukemia virus 1 infection	1.69	4.04e-2	197/219 (89.95%)	CREB1;CALR;ADCY7;...
Cocaine addiction	1.69	3.98e-2	42/49 (85.71%)	CREB1;MAOA;GNAS;...
Circadian entrainment	1.68	3.87e-2	85/97 (87.63%)	CREB1;ADCY7;GNAS;...
Amphetamine addiction	1.66	4.89e-2	57/69 (82.61%)	CREB1;MAOA;GNAS;...
Chagas disease	1.65	4.86e-2	93/102 (91.18%)	CALR;GNAS;ADCY1;...
Oocyte meiosis	1.62	4.97e-2	90/129 (69.77%)	ADCY7;ADCY1;ITPR3;...
Renin-angiotensin system	-1.93	5.78e-3	20/23 (86.96%)	REN;ENPEP;ACE2;...
Ribosome	-2.01	2.89e-3	113/158 (71.52%)	MRPL4;RPL31;RPS20;...
Oxidative phosphorylation	-2.08	5.78e-3	93/133 (69.92%)	ATP6V0A4;ATP6V1A;NDUFA4;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Ewing sarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
SK-ES-1	CVCL_0627	Homo sapiens	1.11uM - 10uM	24H

Brain

Glioma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
GI-1	CVCL_1230	Homo sapiens	1.11uM - 10uM	24H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H

MDA-MB-468	CVCL_0419	Homo sapiens	1.11uM - 10uM	24H

Breast ductal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
T-47D	CVCL_0553	Homo sapiens	1.11uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

SNU-407	CVCL_5004	Homo sapiens	1.11uM - 10uM	24H

Endometrium

Endometrial adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
HEC-108	CVCL_2926	Homo sapiens	1.11uM - 10uM	24H

HEC-1-A	CVCL_0293	Homo sapiens	1.11uM - 10uM	24H

HEC-251	CVCL_2928	Homo sapiens	1.11uM - 10uM	24H

HEC-265	CVCL_2929	Homo sapiens	1.11uM - 10uM	24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
CJM	CVCL_U797	Homo sapiens	1.11uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
JHH-5	CVCL_1320	Homo sapiens	1.11uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
NCI-H1573	CVCL_1483	Homo sapiens	1.11uM - 10uM	24H

NCI-H838	CVCL_1594	Homo sapiens	1.11uM - 10uM	24H

Lung squamous cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
BEN	CVCL_1081	Homo sapiens	1.11uM - 10uM	24H

HCC95	CVCL_1276	Homo sapiens	1.11uM - 10uM	24H

Muscle

Rhabdomyosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-204	CVCL_0134	Homo sapiens	1.11uM - 10uM	24H

Ovary

Ovarian clear cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
OVTOKO	CVCL_3114	Homo sapiens	1.11uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
22Rv1	CVCL_1045	Homo sapiens	1.11uM - 10uM	24H

PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H

IGR-37	CVCL_1303	Homo sapiens	3.33uM - 10uM	24H

Mel-HO	CVCL_1402	Homo sapiens	1.11uM - 10uM	24H

SH-4	CVCL_1692	Homo sapiens	1.11uM - 10uM	24H

Urinary bladder

Bladder carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
BC-3C	CVCL_1079	Homo sapiens	1.11uM - 10uM	24H

Bladder transitional cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
CAL-29	CVCL_1109	Homo sapiens	1.11uM - 10uM	24H