Details of the Drug Pharmacogenomic Perturbation Atlas

Chenodiol Drug Info

474-25-9; Chenix; Chenic acid; Chenodeoxycholate; Gallodesoxycholic acid; Chendol; Chenodesoxycholic acid; Cdca; Chenofalk; Anthropodeoxycholic acid; Anthropodesoxycholic acid; Anthropododesoxycholic acid; Chenodesoxycholsaeure; Xenbilox; Henohol; Chenique Acid; Chenodiol [USAN]; 3alpha,7alpha-Dihydroxy-5beta-cholan-24-oic acid; Sodium chenodeoxycholate; Acido chenodeoxicholico; Chenodesoxycholsaeure [German]; Acide chenodeoxycholique; 7-alpha-Hydroxylithocholic acid; Acidum chenodeoxycholicum

Cross-matching ID

PubChem CID

10133

ChEBI ID

CHEMBL240597

CAS Number

CAS 474-25-9

TTD Drug ID

D03ZTE

VARIDT Drug ID

DR00524

INTEDE Drug ID

DR0295

ACDINA Drug ID

D00118

General Information of Drug (ID: DMQ8JIK)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.20	0.00e+0	34/36 (94.44%)	MCM3;MCM5;FEN1;...
ECM-receptor interaction	2.12	0.00e+0	80/88 (90.91%)	SPP1;LAMB1;COMP;...
Primary immunodeficiency	2.06	0.00e+0	33/38 (86.84%)	TAP1;CD79A;CD3D;...
Proximal tubule bicarbonate reclamation	1.88	5.33e-3	21/23 (91.3%)	CA2;ATP1A2;ATP1A3;...
Ribosome biogenesis in eukaryotes	1.79	2.34e-2	52/108 (48.15%)	NVL;NOP56;GTPBP4;...
Mismatch repair	1.78	3.20e-2	22/23 (95.65%)	MSH6;POLD1;RPA1;...
Non-alcoholic fatty liver disease	-1.67	4.64e-2	126/155 (81.29%)	NDUFA4L2;NDUFB3;IL6;...
Prion disease	-1.67	4.78e-2	209/273 (76.56%)	PSMC1;ATP5PB;PSMC2;...
Cocaine addiction	-1.71	3.84e-2	42/49 (85.71%)	MAOA;GRIA2;CDK5R1;...
Parkinson disease	-1.71	4.11e-2	176/249 (70.68%)	PSMC1;ATP5PB;PSMC2;...
Amphetamine addiction	-1.72	4.33e-2	57/69 (82.61%)	CREB3L2;TH;CREB5;...
Huntington disease	-1.72	4.60e-2	233/306 (76.14%)	PSMC1;ATP5PB;PSMC2;...
Legionellosis	-1.86	1.29e-2	51/57 (89.47%)	CR1;HSPA6;CD14;...
TNF signaling pathway	-1.88	1.08e-2	103/112 (91.96%)	VEGFC;CXCL6;JUN;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.90	1.26e-2	62/70 (88.57%)	ATP6V1G1;JAM3;ATP6V0A4;...
Rheumatoid arthritis	-2.09	1.88e-3	78/93 (83.87%)	TNFRSF11A;ATP6V1E1;IL18;...
Coronavirus disease	-2.13	0.00e+0	215/232 (92.67%)	RPL23A;RPS27;RPL37A;...
Oxidative phosphorylation	-2.20	0.00e+0	93/133 (69.92%)	NDUFA4L2;NDUFB3;NDUFA4;...
IL-17 signaling pathway	-2.35	0.00e+0	84/94 (89.36%)	FOSB;CXCL6;S100A7;...
Ribosome	-2.62	0.00e+0	113/158 (71.52%)	RPL31;RPL32;RPL7A;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H

Normal (Transformed)

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H

Normal (Fibroblast)

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H