Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQ94CT)

• Drug Name: AT9283 Drug Info
• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 135398495
  ChEBI ID: CHEMBL495727
  CAS Number: CAS 896466-04-9
  TTD Drug ID: D05PZB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Oxidative phosphorylation	2.00	9.12e-3	93/133 (69.92%)	ATP6V0E2;CYC1;NDUFA10;...
Ribosome biogenesis in eukaryotes	1.94	9.12e-3	52/108 (48.15%)	DKC1;GTPBP4;NAT10;...
Viral protein interaction with cytokine and cytokine re...	1.82	2.74e-2	84/100 (84%)	CXCL14;CXCL10;CCL2;...
Aminoacyl-tRNA biosynthesis	1.80	2.74e-2	15/66 (22.73%)	NARS2;LARS2;CARS2;...
Collecting duct acid secretion	1.75	4.38e-2	22/27 (81.48%)	CA2;ATP6V0E2;ATP6V0A1;...
Amphetamine addiction	-1.84	3.21e-2	57/69 (82.61%)	PPP1CA;PPP3CC;FOSB;...
Mismatch repair	-1.87	3.21e-2	22/23 (95.65%)	RPA2;POLD3;MLH1;...
Mineral absorption	-2.09	0.00e+0	48/60 (80%)	SLC34A1;HEPH;ATP1B1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
1HAEo-	CVCL_0128	Homo sapiens	10uM	24H	Show ▼
NL20	CVCL_0461	Homo sapiens	10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.04uM - 10uM	6H, 24H, 48H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Normal (Fibroblast)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HFL1	CVCL_4295	Homo sapiens	10uM	24H	Show ▼
IMR-90	CVCL_0347	Homo sapiens	10uM	24H	Show ▼
WI-38	CVCL_0579	Homo sapiens	10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼