Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQDUG4)

• Drug Name: ISIS-CRP Drug Info
• Synonyms: 1-(Tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 172889-27-9; pp2; PP 2; 1-(tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; AG 1879; 1-tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; PP2; 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine; AG-1879; CHEMBL406845; CHEBI:78331; AK-60369; 1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-amine; 3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; C15H16ClN5; 1qpe; 4few; PBBRWFOVCUAONR-UHFFFAOYSA-N; AG1879; PP 2 (AG 1879)
• Cross-matching ID: TTD Drug ID: D06CIJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ether lipid metabolism	2.11	0.00e+0	32/49 (65.31%)	PLPP3;ENPP2;PLPP1;...
Metabolism of xenobiotics by cytochrome P450	1.96	8.49e-3	49/77 (63.64%)	EPHX1;CYP1B1;AKR1C1;...
Histidine metabolism	1.88	1.13e-2	16/22 (72.73%)	HNMT;ALDH2;MAOB;...
Tryptophan metabolism	1.87	8.49e-3	35/42 (83.33%)	CYP1B1;ALDH2;MAOB;...
Sulfur metabolism	1.86	8.49e-3	9/10 (90%)	SELENBP1;MPST;TST;...
Glycerolipid metabolism	1.83	1.13e-2	44/61 (72.13%)	PLPP3;PLPP1;ALDH2;...
Steroid hormone biosynthesis	1.83	9.71e-3	43/61 (70.49%)	AKR1C3;CYP1B1;AKR1C2;...
Other glycan degradation	1.81	1.49e-2	13/18 (72.22%)	FUCA1;HEXA;HEXB;...
Peroxisome	1.71	4.06e-2	72/82 (87.8%)	SOD2;IDH1;CAT;...
Complement and coagulation cascades	1.68	4.59e-2	76/85 (89.41%)	C1R;C1S;CFB;...
IL-17 signaling pathway	-1.67	4.31e-2	84/94 (89.36%)	CCL2;IL1B;SRSF1;...
Renal cell carcinoma	-1.72	3.06e-2	68/69 (98.55%)	PIK3CD;KRAS;PIK3CB;...
Legionellosis	-1.77	1.71e-2	51/57 (89.47%)	CXCL2;SAR1A;IL1B;...
Tight junction	-1.77	1.83e-2	130/169 (76.92%)	CD1A;CD1C;PPP2R1B;...
Colorectal cancer	-1.78	1.88e-2	84/86 (97.67%)	LEF1;BAK1;GRB2;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.79	1.63e-2	62/70 (88.57%)	IKBKG;ATP6V0E1;CXCL2;...
Thyroid cancer	-1.81	1.56e-2	36/37 (97.3%)	NCOA4;LEF1;BAK1;...
Prion disease	-1.82	1.34e-2	209/273 (76.56%)	SEM1;NDUFS6;PIK3CB;...
Yersinia infection	-1.90	6.79e-3	120/137 (87.59%)	CCL2;IL1B;MYD88;...
Salmonella infection	-1.97	0.00e+0	198/249 (79.52%)	TUBB1;IL1B;MYL12B;...
Steroid biosynthesis	-2.03	0.00e+0	19/20 (95%)	LBR;DHCR7;SOAT2;...
Bladder cancer	-2.07	0.00e+0	40/41 (97.56%)	KRAS;CDK4;E2F3;...
Ribosome biogenesis in eukaryotes	-2.12	0.00e+0	52/108 (48.15%)	NXF3;RCL1;REXO2;...
Proteasome	-2.15	0.00e+0	44/46 (95.65%)	PSME3;PSMB5;PSMC6;...
Bacterial invasion of epithelial cells	-2.17	0.00e+0	59/77 (76.62%)	PIK3CD;CTNNA3;PIK3CB;...
Spliceosome	-2.24	0.00e+0	101/150 (67.33%)	LSM5;FUS;DDX5;...
RNA transport	-2.25	0.00e+0	128/186 (68.82%)	ELAC2;RAE1;NUP188;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼