Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQEOD6)

Drug Name
VTP-27999 Drug Info
Synonyms
VTP-27999; C26H41ClN4O5; 6076AC; CS-0311; HY-50768; W-5512; 142C510; Carbamic acid, N-[2-[(R)-(3-chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]-, methyl ester
Cross-matching ID
PubChem CID
16126898
ChEBI ID
CHEMBL1276678
CAS Number
CAS 942142-51-0
TTD Drug ID
D01QSG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.33 0.00e+0 34/36 (94.44%) PCNA;RPA3;PRIM1;...
Proteasome 1.98 0.00e+0 44/46 (95.65%) PSMB6;PSMB3;PSMB4;...
Oxidative phosphorylation 1.87 2.19e-3 93/133 (69.92%) COX7A1;ATP5MC1;NDUFB5;...
Mineral absorption 1.86 1.64e-3 48/60 (80%) MT1E;MT1H;MT1HL1;...
Ribosome 1.85 2.63e-3 113/158 (71.52%) MRPS16;MRPL11;MRPL15;...
Terpenoid backbone biosynthesis 1.79 1.20e-2 18/22 (81.82%) ACAT2;ACAT1;FDPS;...
Nucleotide excision repair 1.77 1.50e-2 40/47 (85.11%) PCNA;RPA3;CETN2;...
Amyotrophic lateral sclerosis 1.75 1.72e-2 267/364 (73.35%) COX7A1;ATP5MC1;SEH1L;...
Mismatch repair 1.70 3.14e-2 22/23 (95.65%) PCNA;RPA3;MSH2;...
Homologous recombination 1.70 3.02e-2 35/41 (85.37%) RPA3;RAD51C;RAD51;...
PPAR signaling pathway 1.70 2.75e-2 66/74 (89.19%) PCK1;ACSL4;LPL;...
Drug metabolism 1.66 3.88e-2 78/151 (51.66%) UGT2B28;CYP2E1;NAT1;...
Pyrimidine metabolism 1.65 3.99e-2 40/56 (71.43%) NT5E;TYMS;ENPP1;...
RNA transport 1.65 3.80e-2 128/186 (68.82%) SEH1L;NXT1;MAGOH;...
Thermogenesis 1.63 3.76e-2 173/232 (74.57%) COX7A1;ATP5MC1;ACSL4;...
Metabolism of xenobiotics by cytochrome P450 1.62 4.47e-2 49/77 (63.64%) CYP1B1;UGT2B28;CYP2E1;...
Herpes simplex virus 1 infection -1.68 4.72e-2 165/498 (33.13%) MAVS;IRF3;PIK3R2;...
Endocrine and other factor-regulated calcium reabsorpti... -1.71 4.49e-2 49/53 (92.45%) AP2B1;ATP1A1;CLTC;...
Arrhythmogenic right ventricular cardiomyopathy -1.72 4.66e-2 70/77 (90.91%) SLC8A2;CACNB3;JUP;...
Salivary secretion -1.73 4.99e-2 76/93 (81.72%) HTN3;ATP1A1;GUCY1A1;...
Relaxin signaling pathway -1.74 4.34e-2 114/129 (88.37%) RELA;NFKBIA;CREB1;...
Notch signaling pathway -1.75 3.54e-2 49/59 (83.05%) MFNG;RFNG;EP300;...
Growth hormone synthesis, secretion and action -1.75 3.85e-2 108/119 (90.76%) ADCY7;MAP2K2;STAT1;...
Focal adhesion -1.76 4.27e-2 180/201 (89.55%) ITGA2B;PPP1CC;PTK2;...
Hypertrophic cardiomyopathy -1.77 3.77e-2 81/90 (90%) RYR2;MYH7;TGFB2;...
ECM-receptor interaction -1.83 2.02e-2 80/88 (90.91%) SV2B;ITGA2B;DAG1;...
Primary immunodeficiency -1.86 2.70e-2 33/38 (86.84%) DCLRE1C;PTPRC;RAG2;...
Amoebiasis -2.00 6.74e-3 99/102 (97.06%) RELA;CD1A;PTK2;...
Dilated cardiomyopathy -2.12 0.00e+0 86/96 (89.58%) RYR2;MYH7;TGFB2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H