Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQFDRC)

Drug Name
Idebenone Drug Info
Synonyms
idebenone; 58186-27-9; Idebenona; Idebenonum; CV 2619; Idebenonum [Latin]; Idebenona [Spanish]; Idebenone [INN:JAN]; CV-2619; 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione; UNII-HB6PN45W4J; BRN 2001459; 6-(10-Hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone; HB6PN45W4J; 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone; CHEBI:31687; JGPMMRGNQUBGND-UHFFFAOYSA-N; 2,5-Cyclohexadiene-1,4-dione, 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-; NCGC00160514-01; AK161748
Cross-matching ID
PubChem CID
3686
ChEBI ID
CHEMBL252556
CAS Number
CAS 58186-27-9
TTD Drug ID
D0MM8N
INTEDE Drug ID
DR0853

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycolysis / Gluconeogenesis 2.16 0.00e+0 56/67 (83.58%) PGAM1;ALDOB;ALDH9A1;...
Neutrophil extracellular trap formation 2.08 0.00e+0 101/189 (53.44%) PPIF;TLR4;CYBA;...
Spliceosome 2.04 0.00e+0 101/150 (67.33%) HSPA1A;HNRNPK;SRSF6;...
Metabolism of xenobiotics by cytochrome P450 2.03 0.00e+0 49/77 (63.64%) GSTP1;GSTA1;GSTM3;...
beta-Alanine metabolism 1.94 8.29e-3 25/30 (83.33%) ALDH9A1;ALDH6A1;ALDH3A1;...
Toll-like receptor signaling pathway 1.91 1.15e-2 94/104 (90.38%) SPP1;CD40;TLR4;...
NOD-like receptor signaling pathway 1.91 9.86e-3 145/181 (80.11%) TLR4;CYBA;HSP90AA1;...
NF-kappa B signaling pathway 1.89 1.21e-2 90/104 (86.54%) CD40;CXCL12;TLR4;...
Lipid and atherosclerosis 1.85 1.23e-2 190/215 (88.37%) CD40;HSPA1A;TLR4;...
Taurine and hypotaurine metabolism 1.84 1.24e-2 8/11 (72.73%) CSAD;ADO;GAD1;...
Drug metabolism 1.80 1.51e-2 78/151 (51.66%) FMO1;GSTP1;GSTA1;...
Tryptophan metabolism 1.80 1.38e-2 35/42 (83.33%) KYNU;ALDH9A1;ECHS1;...
Toxoplasmosis 1.77 2.34e-2 103/112 (91.96%) CD40;GNAI1;HSPA1A;...
Pyruvate metabolism 1.75 2.76e-2 41/47 (87.23%) ALDH9A1;ACACB;ADH1C;...
Arginine and proline metabolism 1.74 2.67e-2 39/50 (78%) GATM;ARG1;ALDH9A1;...
PD-L1 expression and PD-1 checkpoint pathway in cancer 1.74 2.50e-2 79/89 (88.76%) TLR4;PIK3CD;NFATC3;...
Diabetic cardiomyopathy 1.74 2.36e-2 162/203 (79.8%) PPIF;CYBA;PIK3CD;...
Pentose and glucuronate interconversions 1.74 2.22e-2 17/34 (50%) AKR1B10;SORD;AKR1A1;...
Ribosome 1.74 2.11e-2 113/158 (71.52%) RPS5;RPL13;RPL14;...
Coronavirus disease 1.74 2.00e-2 215/232 (92.67%) MX2;TLR4;PIK3CD;...
Th17 cell differentiation 1.72 2.30e-2 95/107 (88.79%) HSP90AA1;NFATC3;JUN;...
Propanoate metabolism 1.71 2.57e-2 30/34 (88.24%) SUCLG2;ALDH6A1;ACACB;...
Th1 and Th2 cell differentiation 1.70 2.76e-2 80/92 (86.96%) NFATC3;JUN;HLA-DQA1;...
Glutathione metabolism 1.70 2.65e-2 43/57 (75.44%) GSTP1;GSTA1;GSTM3;...
Tyrosine metabolism 1.69 2.81e-2 30/36 (83.33%) TYRP1;ALDH3A1;HPD;...
Amoebiasis 1.68 2.81e-2 99/102 (97.06%) GNAS;SERPINB3;TLR4;...
Inflammatory bowel disease 1.68 2.72e-2 58/65 (89.23%) TLR4;JUN;HLA-DQA1;...
Hepatitis B 1.67 2.76e-2 151/162 (93.21%) CASP10;TLR4;PIK3CD;...
RIG-I-like receptor signaling pathway 1.67 2.68e-2 64/70 (91.43%) CASP10;NFKB1;CASP8;...
Osteoclast differentiation 1.66 2.64e-2 117/127 (92.13%) CYBA;PIK3CD;CREB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 2.22uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 2.22uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 2.22uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 2.22uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 2.22uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H