Details of the Drug Pharmacogenomic Perturbation Atlas

Sofosbuvir Drug Info

HSDB 8226; Hepcinat; Hepcvir; Resof; SOFOSBUVIR; Sofosbuvir (PSI-7977, GS-7977); Sofosbuvir [USAN:INN]; Sovaldi (TN); SoviHep

Therapeutic Class

Antiviral Agents

Cross-matching ID

PubChem CID

45375808

ChEBI ID

CHEMBL1259059

CAS Number

CAS 1190307-88-0

VARIDT Drug ID

DR00372

General Information of Drug (ID: DMQI86A)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Toll-like receptor signaling pathway	2.08	0.00e+0	94/104 (90.38%)	SPP1;TLR4;IKBKE;...
Galactose metabolism	2.01	5.05e-3	26/31 (83.87%)	PFKP;HK2;AKR1B10;...
Starch and sucrose metabolism	1.92	6.74e-3	25/36 (69.44%)	GPI;HK2;MGAM;...
Neutrophil extracellular trap formation	1.91	7.58e-3	101/189 (53.44%)	TLR4;C5AR1;PIK3CB;...
Pentose phosphate pathway	1.90	6.06e-3	25/30 (83.33%)	PGD;GPI;TALDO1;...
Glycolysis / Gluconeogenesis	1.90	5.05e-3	56/67 (83.58%)	PGAM1;ENO1;PGK1;...
RNA polymerase	1.89	7.22e-3	23/31 (74.19%)	POLR2J;POLR2B;POLR2I;...
DNA replication	1.87	1.01e-2	34/36 (94.44%)	PRIM1;RFC2;MCM3;...
PD-L1 expression and PD-1 checkpoint pathway in cancer	1.82	1.24e-2	79/89 (88.76%)	TLR4;PRKCQ;PIK3CB;...
Proteasome	1.79	1.82e-2	44/46 (95.65%)	PSMA6;PSMA1;PSMB3;...
Homologous recombination	1.78	1.75e-2	35/41 (85.37%)	BLM;RAD51;BRIP1;...
Mismatch repair	1.77	1.68e-2	22/23 (95.65%)	MLH1;RFC2;RFC5;...
Measles	1.74	2.10e-2	133/139 (95.68%)	TLR4;OAS2;IKBKE;...
Fructose and mannose metabolism	1.74	2.09e-2	30/33 (90.91%)	PFKFB3;PFKP;ALDOC;...
Protein export	1.70	3.23e-2	17/23 (73.91%)	OXA1L;SEC63;SRPRA;...
Spliceosome	1.70	3.22e-2	101/150 (67.33%)	HSPA6;HSPA8;NCBP2;...
Leishmaniasis	1.66	3.98e-2	67/77 (87.01%)	TLR4;MARCKSL1;STAT1;...
Neomycin, kanamycin and gentamicin biosynthesis	1.65	4.10e-2	5/5 (100%)	HK2;HK3;HK1
RNA transport	1.63	4.84e-2	128/186 (68.82%)	EIF5;NCBP2;SUMO3;...
Ferroptosis	1.62	4.85e-2	36/41 (87.8%)	SAT1;NCOA4;PCBP2;...
Renin-angiotensin system	-1.84	3.47e-2	20/23 (86.96%)	THOP1;ANPEP;AGTR1;...
Regulation of lipolysis in adipocytes	-1.92	1.98e-2	52/55 (94.55%)	PIK3R3;NPR1;PTGER3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H

MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 10uM	24H