Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQM2JL)

• Drug Name: Palux Drug Info
• Synonyms: Kaishi; AC1L3YXT; Prestwick0_001018; Prestwick1_001018; CBiol_001943; KBioSS_000208; KBioGR_000208; SPBio_003046; SCHEMBL2962928; KBio2_005344; CHEBI:92915; KBio3_000416; KBio2_002776; KBio3_000415; KBio2_000208; GMVPRGQOIOIIMI-DODZYUBVSA-N; Bio2_000688; Bio1_001207; Bio1_000718; Bio1_000229; Bio2_000208; AKOS032960372; DB00770; API0001428; BRD-K48099440-001-01-7
• Cross-matching ID:
  PubChem CID: 149351
  ChEBI ID: CHEMBL92915
  TTD Drug ID: D0SK2J

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Bile secretion	1.96	1.46e-2	68/90 (75.56%)	AQP1;GNAS;ABCC4;...
Neutrophil extracellular trap formation	-1.74	4.24e-2	101/189 (53.44%)	PLCG2;VWF;PLCG1;...
Salmonella infection	-1.76	4.28e-2	198/249 (79.52%)	S100A10;TLR6;RAB9A;...
Adherens junction	-1.79	3.69e-2	63/71 (88.73%)	TJP1;RAC3;TCF7;...
Yersinia infection	-1.83	1.84e-2	120/137 (87.59%)	CRKL;MAPK8;TNF;...
Fc epsilon RI signaling pathway	-1.84	1.71e-2	57/68 (83.82%)	MAPK8;SOS1;TNF;...
ErbB signaling pathway	-1.89	5.14e-3	79/85 (92.94%)	CRKL;MAPK8;SOS1;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.99	0.00e+0	62/70 (88.57%)	CXCR1;CXCL3;MAPK9;...
Fc gamma R-mediated phagocytosis	-2.01	0.00e+0	79/97 (81.44%)	PLA2G4C;PIK3R1;WAS;...
Bacterial invasion of epithelial cells	-2.03	0.00e+0	59/77 (76.62%)	CTNNA2;CRKL;ARHGEF26;...
Natural killer cell mediated cytotoxicity	-2.04	0.00e+0	99/131 (75.57%)	IFNA4;IFNA21;IFNA10;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲