Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQM7IL)

Drug Name
SAR245409 Drug Info
Cross-matching ID
PubChem CID
16123056
ChEBI ID
CHEMBL124914
CAS Number
CAS 934493-76-2
TTD Drug ID
D01PGR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Sulfur metabolism 2.06 0.00e+0 9/10 (90%) SELENBP1;PAPSS2;TST;...
Alzheimer disease -1.64 4.82e-2 279/369 (75.61%) PIK3CB;MTOR;PSMC5;...
T cell receptor signaling pathway -1.67 3.86e-2 93/104 (89.42%) ITK;SOS1;PIK3CB;...
Pathways of neurodegeneration -1.67 4.07e-2 354/475 (74.53%) PRPH;PDYN;MTOR;...
Citrate cycle (TCA cycle) -1.68 4.29e-2 30/30 (100%) ACO1;ACO2;IDH2;...
Fructose and mannose metabolism -1.68 4.13e-2 30/33 (90.91%) HKDC1;ALDOA;PFKFB2;...
Glycine, serine and threonine metabolism -1.71 3.16e-2 31/40 (77.5%) DLD;GCAT;PSPH;...
Biosynthesis of unsaturated fatty acids -1.74 2.53e-2 21/27 (77.78%) HSD17B4;HACD2;ACAA1;...
Oxidative phosphorylation -1.76 2.21e-2 93/133 (69.92%) ATP4B;ATP4A;SDHC;...
Terpenoid backbone biosynthesis -1.76 2.38e-2 18/22 (81.82%) GGPS1;HMGCR;MVD;...
RIG-I-like receptor signaling pathway -1.78 2.11e-2 64/70 (91.43%) RELA;ATG12;MAPK9;...
Spinocerebellar ataxia -1.78 2.30e-2 128/143 (89.51%) PIK3CB;PDYN;MTOR;...
Arginine and proline metabolism -1.81 2.25e-2 39/50 (78%) CNDP2;AOC1;NOS2;...
Renal cell carcinoma -1.81 2.34e-2 68/69 (98.55%) RAPGEF1;SOS1;PIK3CB;...
HIF-1 signaling pathway -1.83 1.93e-2 105/109 (96.33%) SERPINE1;CAMK2A;RPS6KB1;...
Protein processing in endoplasmic reticulum -1.86 2.01e-2 127/171 (74.27%) STUB1;DNAJC1;SKP1;...
Huntington disease -1.90 1.17e-2 233/306 (76.14%) MTOR;PSMC5;NDUFS6;...
Amyotrophic lateral sclerosis -1.91 1.41e-2 267/364 (73.35%) NUP160;SDHC;NDUFA3;...
Parkinson disease -1.94 1.05e-2 176/249 (70.68%) KLC1;CAMK2A;SDHC;...
Prion disease -2.10 0.00e+0 209/273 (76.56%) SDHC;NDUFA3;C1QB;...
Steroid biosynthesis -2.13 0.00e+0 19/20 (95%) TM7SF2;HSD17B7;FDFT1;...
Proteasome -2.44 0.00e+0 44/46 (95.65%) PSMC5;PSMD13;ADRM1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.08uM - 10uM 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.08uM - 10uM 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.08uM - 10uM 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H