Details of the Drug Pharmacogenomic Perturbation Atlas

Gamolenic acid Drug Info

gamma-Linolenic acid; GAMOLENIC ACID; 506-26-3; (6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid; (Z,Z,Z)-6,9,12-Octadecatrienoic acid; CCRIS 7668; UNII-78YC2MAX4O; Acidum gamolenicum [Latin]; Acido gamolenico [Spanish]; Acide gamolenique [French]; 6,9,12-Octadecatrienoic acid, (Z,Z,Z)-; Gamolenic acid [INN:BAN]; (6,9,12)-linolenic acid; all-cis-6,9,12-Octadecatrienoic acid; cis,cis,cis-6,9,12-Octadecatrienoic acid; 6Z,9Z,12Z-octadecatrienoic acid; 78YC2MAX4O; cis-Delta(6,9,12)-octadecatrienoic acid; CHEMBL464982; CHEBI:28661; Epogam (TN); gamma-linolenic acid

Cross-matching ID

PubChem CID

5280933

ChEBI ID

CHEMBL464982

CAS Number

CAS 506-26-3

TTD Drug ID

D0UE9X

INTEDE Drug ID

DR1995

General Information of Drug (ID: DMQN30Z)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Mineral absorption	-1.67	4.30e-2	48/60 (80%)	STEAP1;ATP7B;FTH1;...
Kaposi sarcoma-associated herpesvirus infection	-1.69	3.98e-2	172/193 (89.12%)	TICAM1;CXCL3;PIK3R2;...
Pentose phosphate pathway	-1.70	3.89e-2	25/30 (83.33%)	TKTL1;GPI;TALDO1;...
Glyoxylate and dicarboxylate metabolism	-1.71	3.36e-2	23/30 (76.67%)	PCCB;ACO1;SHMT1;...
IL-17 signaling pathway	-1.72	3.36e-2	84/94 (89.36%)	PTGS2;DEFB4A;IKBKG;...
Influenza A	-1.72	3.52e-2	156/172 (90.7%)	TICAM1;PIK3R2;NLRP3;...
Propanoate metabolism	-1.72	3.70e-2	30/34 (88.24%)	LDHC;ALDH6A1;ACADS;...
Rheumatoid arthritis	-1.74	3.64e-2	78/93 (83.87%)	ITGAL;ATP6V0B;ITGB2;...
Glutathione metabolism	-1.77	3.87e-2	43/57 (75.44%)	CHAC1;G6PD;MGST2;...
Pertussis	-1.79	3.58e-2	64/76 (84.21%)	ITGAM;GNAI2;CALML3;...
Non-alcoholic fatty liver disease	-1.80	3.73e-2	126/155 (81.29%)	PKLR;ADIPOQ;MLX;...
Oxidative phosphorylation	-1.83	3.22e-2	93/133 (69.92%)	NDUFB1;ATP4A;ATP5MF;...
Nicotinate and nicotinamide metabolism	-1.89	1.28e-2	25/35 (71.43%)	AOX1;SIRT5;SIRT2;...
Protein processing in endoplasmic reticulum	-1.90	1.12e-2	127/171 (74.27%)	SEC23B;RNF5;SEC13;...
Ferroptosis	-1.91	1.34e-2	36/41 (87.8%)	PRNP;FTH1;PCBP2;...
Metabolism of xenobiotics by cytochrome P450	-1.94	1.12e-2	49/77 (63.64%)	MGST2;CYP1A1;ALDH3A1;...
Staphylococcus aureus infection	-2.00	3.73e-3	72/95 (75.79%)	KRT17;ITGAM;ITGAL;...
Legionellosis	-2.02	0.00e+0	51/57 (89.47%)	NAIP;CASP8;CLK4;...
Malaria	-2.16	0.00e+0	44/50 (88%)	CSF3;ITGAL;THBS4;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	1.11uM	6H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H

Prostate

Prostate carcinoma

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H