Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQR7TZ)

Drug Name
GSK-3beta inhibitor II Drug Info
Synonyms GSK-3b inhibitor II
Cross-matching ID
PubChem CID
6539732
ChEBI ID
CHEMBL288064
CAS Number
CAS 478482-75-6
TTD Drug ID
D01MEP

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.51 0.00e+0 34/36 (94.44%) POLE2;FEN1;RFC3;...
Ribosome biogenesis in eukaryotes 2.42 0.00e+0 52/108 (48.15%) GNL3;DKC1;RRP7A;...
Base excision repair 1.99 6.34e-3 29/33 (87.88%) POLE2;FEN1;PCNA;...
Proteasome 1.97 6.34e-3 44/46 (95.65%) PSMD8;PSMA3;PSMB8;...
Cell cycle 1.95 5.07e-3 110/124 (88.71%) CHEK2;CDC45;MYC;...
Pyrimidine metabolism 1.86 6.34e-3 40/56 (71.43%) TYMS;UPP1;UCK2;...
One carbon pool by folate 1.75 1.90e-2 15/20 (75%) TYMS;GART;SHMT2;...
Mismatch repair 1.75 1.82e-2 22/23 (95.65%) RFC3;RFC4;PCNA;...
Fanconi anemia pathway 1.71 2.40e-2 36/54 (66.67%) FANCG;USP1;ATR;...
RNA transport 1.70 2.22e-2 128/186 (68.82%) PRMT5;NUP85;NXT1;...
Non-homologous end-joining 1.69 2.31e-2 11/13 (84.62%) FEN1;PRKDC;XRCC5;...
Homologous recombination 1.69 2.11e-2 35/41 (85.37%) POLD2;RPA2;RAD54B;...
RNA polymerase 1.64 3.51e-2 23/31 (74.19%) POLR1E;POLR3D;POLR2H;...
Nucleotide excision repair 1.61 4.85e-2 40/47 (85.11%) POLE2;RFC3;RFC4;...
Regulation of lipolysis in adipocytes -1.84 4.37e-2 52/55 (94.55%) PIK3CA;AQP7;PRKACA;...
Gastric acid secretion -1.98 1.46e-2 63/76 (82.89%) ADCY6;KCNJ10;HRH2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 12.5uM 6H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.08uM - 10uM 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.08uM - 10uM 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.08uM - 10uM 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 12.5uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.05uM - 12.5uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H