Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQTJSX)

• Drug Name: Fluvoxamine Drug Info
• Synonyms: Dumyrox; Fluvoxamina; Fluvoxaminum; Fluvoxamina [INN-Spanish]; Fluvoxamine (INN); Fluvoxamine [INN:BAN]; Fluvoxamine-CR; Fluvoxaminum [INN-Latin]; Luvox (TN); (1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan-1-one O-(2-aminoethyl)oxime; 2-[(E)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine; 2-[({5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino)oxy]ethanamine
• Therapeutic Class: Antidepressants
• Cross-matching ID:
  PubChem CID: 5324346
  ChEBI ID: CHEMBL814
  CAS Number: CAS 54739-18-3
  TTD Drug ID: D03HFG
  VARIDT Drug ID: DR00390
  ACDINA Drug ID: D00290

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.26	0.00e+0	19/20 (95%)	MSMO1;CYP51A1;SQLE;...
Long-term potentiation	2.11	0.00e+0	61/67 (91.04%)	KRAS;PPP3CB;CALML4;...
Dopaminergic synapse	2.07	0.00e+0	115/132 (87.12%)	KIF5C;PPP3CB;CALML4;...
GnRH signaling pathway	1.96	5.81e-3	80/93 (86.02%)	CDC42;KRAS;JUN;...
Amphetamine addiction	1.92	6.97e-3	57/69 (82.61%)	JUN;PPP3CB;CALML4;...
Melanogenesis	1.90	5.81e-3	74/101 (73.27%)	KRAS;TYR;CTNNB1;...
Inflammatory mediator regulation of TRP channels	1.82	8.30e-3	82/98 (83.67%)	P2RY2;PRKCH;CALML4;...
Circadian entrainment	1.79	1.45e-2	85/97 (87.63%)	PER3;CALML4;CAMK2A;...
Endocrine and other factor-regulated calcium reabsorpti...	1.75	2.58e-2	49/53 (92.45%)	ATP2B4;ATP2B1;ATP1B3;...
Gap junction	1.74	2.44e-2	72/88 (81.82%)	TUBB2A;TUBB;KRAS;...
GnRH secretion	1.71	3.27e-2	60/64 (93.75%)	SPP1;KRAS;ARRB2;...
Adrenergic signaling in cardiomyocytes	1.70	3.97e-2	130/150 (86.67%)	ATP2B4;TPM4;CALML4;...
Gastric acid secretion	1.69	4.11e-2	63/76 (82.89%)	CCKBR;CALML4;CAMK2A;...
Long-term depression	1.67	4.23e-2	55/60 (91.67%)	KRAS;GNAQ;PRKCA;...
Oocyte meiosis	1.67	4.11e-2	90/129 (69.77%)	PLK1;PPP3CB;CALML4;...
Proteasome	-1.89	1.13e-2	44/46 (95.65%)	PSMD9;PSMB4;PSMD1;...
Mineral absorption	-2.12	0.00e+0	48/60 (80%)	SLC30A1;MT1HL1;MT2A;...
Porphyrin and chlorophyll metabolism	-2.13	0.00e+0	23/43 (53.49%)	BLVRA;ALAS1;FECH;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼