Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQU4XM)

Drug Name
7,8-dihydrobiopterin Drug Info
Synonyms
Quinonoid dihydrobiopterin; q-BH2; L-erythro-q-dihydrobiopterin; dihydrobiopterin; L-erythro-7,8-Dihydrobiopterin; L-erythro-dihydrobiopterin; 7,8-Dihydro-L-biopterin; 6779-87-9; 2-amino-6-((1r,2s)-1,2-dihydroxypropyl)-7,8-dihydro-4(1h)-pteridinone; 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-7,8-dihydropteridin-4(3H)-one; 2toh; 4(1H)-pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-7,8-dihydro-; 4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-, [S-(R*,S*)]-; 4(1H)-Pteridinone; 7,8-Dihydro-L-Biopterin
Cross-matching ID
PubChem CID
135398687
ChEBI ID
CHEMBL43029
CAS Number
CAS 6779-87-9
TTD Drug ID
D0F3XT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
mTOR signaling pathway -1.68 4.82e-2 114/154 (74.03%) MAPK1;PIK3R1;EIF4EBP1;...
ErbB signaling pathway -1.72 3.41e-2 79/85 (92.94%) PLCG2;MAPK1;PIK3R1;...
Renal cell carcinoma -1.73 3.06e-2 68/69 (98.55%) EGLN3;ARNT2;PIK3CD;...
Autophagy -1.73 3.24e-2 113/169 (66.86%) PIK3CD;MAPK8;PIK3R2;...
Epithelial cell signaling in Helicobacter pylori infect... -1.77 2.06e-2 62/70 (88.57%) ADAM17;MAP2K4;ADAM10;...
Pancreatic secretion -1.78 2.20e-2 87/102 (85.29%) CELA3B;CELA2B;CPA1;...
Salivary secretion -1.78 2.16e-2 76/93 (81.72%) PRB1;ADCY1;CALML5;...
Thyroid hormone synthesis -1.80 2.01e-2 66/75 (88%) ADCY1;ATF2;DUOX1;...
Arginine biosynthesis -1.83 1.38e-2 17/22 (77.27%) ASS1;GLS2;CPS1;...
Pentose and glucuronate interconversions -1.83 1.50e-2 17/34 (50%) UGT2B28;KL;CRYL1;...
Other glycan degradation -1.91 1.38e-3 13/18 (72.22%) HEXA;MAN2B2;HEXB;...
Riboflavin metabolism -1.91 1.53e-3 7/8 (87.5%) ENPP1;RFK;ACP5
Collecting duct acid secretion -1.91 1.72e-3 22/27 (81.48%) ATP6V0C;ATP6V0A4;ATP6V0D1;...
Vibrio cholerae infection -1.94 1.97e-3 44/50 (88%) ATP6AP1;ATP6V0C;ATP6V0A4;...
Gastric acid secretion -1.94 2.29e-3 63/76 (82.89%) CFTR;CCKBR;ADCY1;...
Glycine, serine and threonine metabolism -1.96 0.00e+0 31/40 (77.5%) PIPOX;SHMT2;PHGDH;...
Mineral absorption -1.98 0.00e+0 48/60 (80%) FTL;MT1H;MT1HL1;...
Protein processing in endoplasmic reticulum -2.02 0.00e+0 127/171 (74.27%) EIF2S1;HSPA6;DNAJB2;...
Cysteine and methionine metabolism -2.16 0.00e+0 43/50 (86%) MAT1A;AHCY;BHMT2;...
Ferroptosis -2.21 0.00e+0 36/41 (87.8%) ACSL3;SLC3A2;GCLC;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H