Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQU8B1)

• Drug Name: WB-4101 Drug Info
• Synonyms: WB-4101; WB4101; WB 4101; (2-(2',6'-Dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane; (2-(2',6'-Dimethoxy)phenoxyethylamino)methylbenzodioxan; 613-67-2; CHEMBL25554; CHEBI:64098; N-(2-(2,6-Dimethoxyphenoxy)ethyl)-2,3-dihydro-1,4-benzodioxin-2-methanamine; 1,4-Benzodioxin-2-methanamine, N-(2-(2,6-dimethoxyphenoxy)ethyl)-2,3-dihydro-; N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine; 1,4-benzodioxin-2-methanamine, n-[2-(2,6-dimethoxyphenoxy)ethyl]-2,3-dihydro-; MLS000859914
• Cross-matching ID:
  PubChem CID: 5685
  ChEBI ID: CHEMBL25554
  CAS Number: CAS 613-67-2
  TTD Drug ID: D03QMR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
AGE-RAGE signaling pathway in diabetic complications	-1.67	4.68e-2	97/100 (97%)	SELE;PIM1;SERPINE1;...
Ascorbate and aldarate metabolism	-1.72	4.30e-2	15/30 (50%)	RGN;ALDH2;UGT2B15;...
Retinol metabolism	-1.73	4.02e-2	41/68 (60.29%)	ADH1A;CYP3A4;RDH16;...
Staphylococcus aureus infection	-1.73	4.52e-2	72/95 (75.79%)	C5;KRT33A;KRT14;...
Cardiac muscle contraction	-1.76	3.77e-2	64/87 (73.56%)	CACNG2;CACNG1;COX7B;...
Hypertrophic cardiomyopathy	-1.78	3.91e-2	81/90 (90%)	MYH7;DMD;IL6;...
Focal adhesion	-1.79	3.71e-2	180/201 (89.55%)	COL9A1;LAMB4;FLNB;...
Nicotine addiction	-1.83	2.69e-2	32/40 (80%)	GRIN2C;GRIN2D;GABRR1;...
Complement and coagulation cascades	-1.85	3.26e-2	76/85 (89.41%)	KLKB1;PLAUR;F2RL2;...
Protein digestion and absorption	-1.91	2.93e-2	78/103 (75.73%)	COL5A3;KCNQ1;KCNN4;...
ECM-receptor interaction	-2.10	9.78e-3	80/88 (90.91%)	HSPG2;LAMC3;COL9A2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲