Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQVRZH)

Drug Name
Vitamin B3 Drug Info
Synonyms Niacin (TN); Niacinamide (TN); Nicotinamide (TN)
Cross-matching ID
PubChem CID
938
ChEBI ID
CHEMBL15940
CAS Number
CAS 59-67-6
TTD Drug ID
D0N0ES
INTEDE Drug ID
DR2115
ACDINA Drug ID
D00466

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 2.17 0.00e+0 110/124 (88.71%) CCNB1;MAD2L1;SMC1A;...
Fanconi anemia pathway 1.86 1.30e-2 36/54 (66.67%) FANCI;RPA3;RMI1;...
Pantothenate and CoA biosynthesis 1.85 1.04e-2 14/21 (66.67%) DPYD;AASDHPPT;ENPP1;...
Drug metabolism 1.82 1.30e-2 78/151 (51.66%) DPYD;GSTA1;ADH1B;...
Metabolism of xenobiotics by cytochrome P450 1.70 4.77e-2 49/77 (63.64%) AKR7A2;GSTA1;ADH1B;...
MAPK signaling pathway -1.66 4.85e-2 272/294 (92.52%) PPP5C;NTRK2;ERBB3;...
Toll-like receptor signaling pathway -1.67 4.45e-2 94/104 (90.38%) CXCL8;TRAF3;TLR6;...
Phagosome -1.68 3.93e-2 118/152 (77.63%) DYNC1I1;SEC61B;RAB7A;...
Long-term potentiation -1.69 3.53e-2 61/67 (91.04%) GRIA1;PPP3CA;PRKACA;...
Bladder cancer -1.69 3.37e-2 40/41 (97.56%) HBEGF;MAPK1;DAPK2;...
Lipid and atherosclerosis -1.69 3.59e-2 190/215 (88.37%) PIK3CA;RAC1;MAPK14;...
Salmonella infection -1.70 3.41e-2 198/249 (79.52%) MAPK1;FLNC;PLEKHM1;...
Fc gamma R-mediated phagocytosis -1.71 3.43e-2 79/97 (81.44%) RAF1;PLPP1;PIK3CA;...
Apoptosis -1.74 2.95e-2 126/168 (75%) RIPK1;BIRC7;MCL1;...
NF-kappa B signaling pathway -1.74 3.22e-2 90/104 (86.54%) IKBKG;EDAR;CARD10;...
Leishmaniasis -1.75 3.39e-2 67/77 (87.01%) MAPK11;IRAK1;IRAK4;...
Synaptic vesicle cycle -1.75 3.76e-2 63/78 (80.77%) ATP6V0C;SLC6A9;ATP6V1F;...
Dilated cardiomyopathy -1.76 3.65e-2 86/96 (89.58%) ADCY3;CACNG2;ADCY6;...
Hypertrophic cardiomyopathy -1.77 3.96e-2 81/90 (90%) CACNG2;EMD;CACNB2;...
Neutrophil extracellular trap formation -1.80 3.33e-2 101/189 (53.44%) CLCN4;RAF1;PIK3CA;...
Legionellosis -1.86 9.23e-3 51/57 (89.47%) RELA;NFKB2;VCP;...
Epithelial cell signaling in Helicobacter pylori infect... -1.89 1.15e-2 62/70 (88.57%) ATP6V1G1;MAPK13;HBEGF;...
Thyroid cancer -1.98 0.00e+0 36/37 (97.3%) TFG;TPR;PAX8;...
Osteoclast differentiation -2.02 0.00e+0 117/127 (92.13%) SIRPB1;LILRB4;CSF1;...
Mitophagy -2.22 0.00e+0 56/68 (82.35%) RAB7A;RHOT2;OPTN;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 20uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 2.5uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 2.5uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H