Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQW3A9)

Drug Name
[3H]naltrindole Drug Info
Synonyms
Naltrindole; UNII-G167Z38QA4; 111555-53-4; CHEBI:81528; G167Z38QA4; [3H]-naltrindole; 17-Cyclopropylmethyl-6,7-dehydro-4,5-epoxy-3,14-dihydroxy-6,7,2',3'-indolomorphinan; CHEMBL1237164; (4bs,8r,8as,14br)-7-(Cyclopropylmethyl)-5,6,7,8,14,14b-Hexahydro-4,8-Methano[1]benzofuro[2,3-A]pyrido[4,3-B]carbazole-1,8a(9h)-Diol; 4,8-Methanobenzofuro(2,3-a)pyrido(4,3-b)carbazole-1,8a(9H)-diol, 7-(cyclopropylmethyl)-5,6,7,8,14,14b-hexahydro-, (8R-(4bS*,8alpha,8abeta,14bbeta))-; NTI; EJ4; [3H]-naltrindole
Cross-matching ID
PubChem CID
5497186
ChEBI ID
CHEMBL567175
CAS Number
CAS 111555-53-4
TTD Drug ID
D08IXN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glyoxylate and dicarboxylate metabolism 2.23 0.00e+0 23/30 (76.67%) GLUL;PCCA;ACAT2;...
Terpenoid backbone biosynthesis 2.22 0.00e+0 18/22 (81.82%) HMGCS1;HMGCS2;ACAT2;...
Steroid biosynthesis 2.18 0.00e+0 19/20 (95%) MSMO1;DHCR24;SQLE;...
Butanoate metabolism 2.06 0.00e+0 23/28 (82.14%) HMGCS1;HMGCS2;ACAT2;...
Valine, leucine and isoleucine degradation 2.04 0.00e+0 42/48 (87.5%) HMGCS1;HMGCS2;PCCA;...
Sulfur metabolism 1.99 0.00e+0 9/10 (90%) TST;SUOX;PAPSS2;...
Synthesis and degradation of ketone bodies 1.98 0.00e+0 9/10 (90%) HMGCS1;HMGCS2;ACAT2;...
Tryptophan metabolism 1.90 3.13e-3 35/42 (83.33%) KYNU;ACAT2;ACAT1;...
Complement and coagulation cascades 1.90 2.78e-3 76/85 (89.41%) TFPI;CLU;C1R;...
Primary bile acid biosynthesis 1.76 1.92e-2 15/17 (88.24%) AMACR;CH25H;CYP7A1;...
Sulfur relay system 1.76 1.90e-2 5/8 (62.5%) TST;MPST;NFS1
Peroxisome 1.73 2.57e-2 72/82 (87.8%) SLC27A2;AMACR;ACSL3;...
Small cell lung cancer -1.74 4.87e-2 90/92 (97.83%) CASP3;BCL2;LAMC2;...
ECM-receptor interaction -1.76 4.62e-2 80/88 (90.91%) COL6A1;COL9A1;COL1A1;...
AGE-RAGE signaling pathway in diabetic complications -1.99 0.00e+0 97/100 (97%) PLCB2;CASP3;BCL2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H