General Information of Drug (ID: DMQWGID)

Drug Name
Acipimox Drug Info
Synonyms Monted; Nedios; Olbemox; Olbetam; K 9321
Cross-matching ID
PubChem CID
5310993
ChEBI ID
CHEMBL345714
CAS Number
CAS 51037-30-0
TTD Drug ID
D0S1NZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.85 5.95e-2 34/36 (94.44%) PCNA;MCM5;FEN1;...
Graft-versus-host disease 1.79 7.93e-2 32/42 (76.19%) GZMB;HLA-DQB1;PRF1;...
Base excision repair 1.75 9.26e-2 29/33 (87.88%) PCNA;FEN1;POLE2;...
Type I diabetes mellitus 1.73 7.44e-2 38/43 (88.37%) GZMB;CPE;HLA-DQB1;...
Allograft rejection 1.71 7.93e-2 32/38 (84.21%) GZMB;HLA-DQB1;PRF1;...
Autoimmune thyroid disease 1.53 3.85e-1 46/53 (86.79%) GZMB;HLA-DQB1;PRF1;...
Antigen processing and presentation 1.48 4.29e-1 60/78 (76.92%) CTSB;CTSL;HLA-DQB1;...
Systemic lupus erythematosus 1.47 4.02e-1 45/135 (33.33%) C2;ACTN1;SNRPB;...
N-Glycan biosynthesis 1.47 3.84e-1 38/50 (76%) MAN2A1;ALG8;MOGS;...
Cell cycle 1.43 4.62e-1 110/124 (88.71%) PCNA;MCM5;E2F2;...
Pyrimidine metabolism 1.43 4.35e-1 40/56 (71.43%) TYMS;DTYMK;CDA;...
Cholesterol metabolism 1.39 4.46e-1 44/50 (88%) APOA1;VDAC1;APOA2;...
Epstein-Barr virus infection 1.39 4.21e-1 189/202 (93.56%) CXCL10;RELB;HES1;...
Viral carcinogenesis 1.39 4.01e-1 149/203 (73.4%) DNAJA3;BAD;ACTN1;...
Various types of N-glycan biosynthesis 1.37 4.36e-1 26/39 (66.67%) MAN2A1;RPN2;DAD1;...
Hepatocellular carcinoma 1.33 4.50e-1 135/168 (80.36%) FZD5;E2F2;MET;...
Ubiquitin mediated proteolysis 1.32 4.41e-1 87/140 (62.14%) NEDD4L;SOCS1;MGRN1;...
Intestinal immune network for IgA production 1.32 4.24e-1 38/48 (79.17%) HLA-DQB1;HLA-DPA1;CD40;...
Primary immunodeficiency 1.32 4.23e-1 33/38 (86.84%) CD79A;CD40;CD8A;...
Bacterial invasion of epithelial cells 1.30 4.59e-1 59/77 (76.62%) MET;ACTB;FN1;...
Glycolysis / Gluconeogenesis 1.30 4.45e-1 56/67 (83.58%) PGK1;PCK1;ALDOA;...
Central carbon metabolism in cancer 1.30 4.35e-1 67/70 (95.71%) MET;FGFR3;SLC7A5;...
Phagosome 1.29 4.27e-1 118/152 (77.63%) ACTB;COLEC12;SFTPD;...
Porphyrin and chlorophyll metabolism 1.28 4.58e-1 23/43 (53.49%) UGT2B28;CP;UGT2B17;...
Glutathione metabolism 1.28 4.53e-1 43/57 (75.44%) ANPEP;LAP3;GSTA1;...
Viral myocarditis 1.27 4.59e-1 53/60 (88.33%) ACTB;CAV1;HLA-DQB1;...
Prostate cancer 1.27 4.58e-1 93/97 (95.88%) PLAT;E2F2;BAD;...
mTOR signaling pathway 1.23 4.67e-1 114/154 (74.03%) FZD5;SGK1;SLC7A5;...
Pancreatic cancer 1.22 4.58e-1 75/76 (98.68%) E2F2;BAD;GADD45G;...
Human papillomavirus infection 1.21 4.64e-1 284/331 (85.8%) FZD5;GNAS;HES1;...
Oxidative phosphorylation -0.99 7.46e-1 93/133 (69.92%) ATP5PF;COX6C;ATP5MC3;...
Transcriptional misregulation in cancer -0.99 7.52e-1 158/192 (82.29%) AFF1;KMT2A;JMJD1C;...
Synthesis and degradation of ketone bodies -1.00 7.46e-1 9/10 (90%) BDH2;ACAT1;HMGCS1
Thyroid cancer -1.01 7.46e-1 36/37 (97.3%) LEF1;TCF7L2;TPM3;...
Parathyroid hormone synthesis, secretion and action -1.01 7.50e-1 98/106 (92.45%) CDKN1A;ADCY8;CYP24A1;...
Fatty acid degradation -1.01 7.52e-1 40/43 (93.02%) HADHB;ACAA2;ACSBG1;...
Mitophagy -1.01 7.49e-1 56/68 (82.35%) GABARAPL1;SP1;SQSTM1;...
Coronavirus disease -1.03 7.49e-1 215/232 (92.67%) IL1B;RPL26;SELP;...
ECM-receptor interaction -1.30 6.73e-1 80/88 (90.91%) ITGA2B;TNXB;COL9A3;...
Phosphonate and phosphinate metabolism -1.31 6.57e-1 5/6 (83.33%) CHPT1
Valine, leucine and isoleucine degradation -1.32 6.48e-1 42/48 (87.5%) AOX1;DLD;PCCA;...
Lipid and atherosclerosis -1.32 6.48e-1 190/215 (88.37%) IL1B;NCF2;BCL2L1;...
Glyoxylate and dicarboxylate metabolism -1.33 6.41e-1 23/30 (76.67%) GLUL;DLD;PCCA;...
Selenocompound metabolism -1.34 6.66e-1 11/17 (64.71%) CTH;KYAT3;PAPSS2
RNA polymerase -1.34 7.05e-1 23/31 (74.19%) POLR2C;POLR2A;POLR3K;...
RNA degradation -1.34 7.25e-1 53/79 (67.09%) LSM6;DCP1A;CNOT4;...
Necroptosis -1.36 6.97e-1 113/159 (71.07%) STAT2;CAMK2B;SQSTM1;...
GnRH secretion -1.36 7.48e-1 60/64 (93.75%) GABBR1;GPER1;PIK3R3;...
Gastric acid secretion -1.38 6.87e-1 63/76 (82.89%) CAMK2B;ITPR1;ADCY1;...
Cardiac muscle contraction -1.40 6.76e-1 64/87 (73.56%) SLC8A1;MYL2;ASPH;...
Salivary secretion -1.41 6.71e-1 76/93 (81.72%) ATP1A3;CST4;ATP1B3;...
IL-17 signaling pathway -1.50 3.76e-1 84/94 (89.36%) FADD;IL5;NFKBIA;...
Basal transcription factors -1.50 4.23e-1 37/45 (82.22%) TAF7L;GTF2F1;GTF2H1;...
Steroid biosynthesis -1.50 4.29e-1 19/20 (95%) DHCR7;HSD17B7;NSDHL;...
Protein digestion and absorption -1.53 4.03e-1 78/103 (75.73%) SLC8A1;SLC1A5;COL5A3;...
Apelin signaling pathway -1.56 3.83e-1 117/137 (85.4%) GNAI3;PLCB2;SLC8A1;...
Fatty acid elongation -1.56 4.68e-1 19/27 (70.37%) HACD1;HADHB;ACAA2;...
Tryptophan metabolism -1.65 2.92e-1 35/42 (83.33%) KMO;CYP1A1;ALDH8A1;...
Sulfur metabolism -1.68 3.12e-1 9/10 (90%) SELENBP1;SQOR;TST;...
Legionellosis -1.69 5.94e-1 51/57 (89.47%) IL1B;NAIP;BNIP3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 20uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H