Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMQXPA5)

Drug Name
DNQX Drug Info
Synonyms
dnqx; 2379-57-9; 6,7-dinitro-1,4-dihydroquinoxaline-2,3-dione; FG-9041; FG 9041; UNII-62T278S1MX; 6,7-Dinitroquinoxaline-2,3-dione (DNQX); 2,3-Quinoxalinedione, 1,4-dihydro-6,7-dinitro-; 6,7-Dinitroquinoxaline-2,3(1H,4H)-dione; 62T278S1MX; 6,7-Dinitro-1,4-dihydro-quinoxaline-2,3-dione; SR-01000075442; 1ftl; Tocris-0189; AC1MZKE9; Lopac-D-0540; Biomol-NT_000182; Oprea1_127694; Lopac0_000345; MLS000705107; SCHEMBL594575; SCHEMBL8128055; BPBio1_001176; CHEMBL155265; C8H4N4O6; CHEBI:93492; CTK8F7031; DTXSID60178476; MolPort-003-846-931
Cross-matching ID
PubChem CID
3899541
ChEBI ID
CHEMBL155265
CAS Number
CAS 2379-57-9
TTD Drug ID
D05KQC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.90 3.76e-2 34/36 (94.44%) MCM5;FEN1;PCNA;...
Complement and coagulation cascades -1.65 4.56e-2 76/85 (89.41%) F8;SERPINE1;ITGAX;...
VEGF signaling pathway -1.67 4.06e-2 50/59 (84.75%) MAP2K2;BAD;PRKCA;...
Natural killer cell mediated cytotoxicity -1.68 4.20e-2 99/131 (75.57%) PIK3CD;IFNB1;NCR3;...
Citrate cycle (TCA cycle) -1.68 4.42e-2 30/30 (100%) ACO1;CS;DLAT;...
Ascorbate and aldarate metabolism -1.68 4.11e-2 15/30 (50%) UGT2B15;ALDH2;AKR1A1;...
Glycosaminoglycan degradation -1.69 4.21e-2 19/19 (100%) IDUA;GLB1;GALNS;...
Folate biosynthesis -1.70 4.23e-2 23/26 (88.46%) PAH;GGH;MOCS2;...
Pantothenate and CoA biosynthesis -1.72 4.01e-2 14/21 (66.67%) DPYD;BCAT1;PPCS;...
Porphyrin and chlorophyll metabolism -1.72 4.12e-2 23/43 (53.49%) PPOX;HMBS;UGT2B15;...
Metabolism of xenobiotics by cytochrome P450 -1.75 3.28e-2 49/77 (63.64%) GSTA1;CYP2A13;GSTM1;...
Sulfur metabolism -1.76 3.14e-2 9/10 (90%) PAPSS1;SELENBP1;MPST;...
Alanine, aspartate and glutamate metabolism -1.76 3.42e-2 27/37 (72.97%) GLUD1;NIT2;PPAT;...
Tryptophan metabolism -1.77 3.26e-2 35/42 (83.33%) DLST;KMO;CYP1A1;...
Glycine, serine and threonine metabolism -1.78 3.35e-2 31/40 (77.5%) SHMT2;MAOA;GLDC;...
Cholesterol metabolism -1.80 2.82e-2 44/50 (88%) LPL;APOA4;APOC1;...
Non-alcoholic fatty liver disease -1.84 1.97e-2 126/155 (81.29%) PIK3R2;PPARG;NDUFA1;...
PPAR signaling pathway -1.84 2.30e-2 66/74 (89.19%) LPL;FABP4;PPARG;...
Pyruvate metabolism -1.84 2.76e-2 41/47 (87.23%) ADH1B;PKM;ME2;...
Steroid hormone biosynthesis -1.88 2.82e-2 43/61 (70.49%) HSD3B1;CYP3A4;CYP19A1;...
Mineral absorption -2.12 0.00e+0 48/60 (80%) ATOX1;SLC11A2;MT2A;...
Ferroptosis -2.20 0.00e+0 36/41 (87.8%) GPX4;SLC11A2;MAP1LC3B;...
Glycolysis / Gluconeogenesis -2.21 0.00e+0 56/67 (83.58%) PDHB;PFKM;HK3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
SK-N-SH CVCL_0531 Homo sapiens 0.04uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H