General Information of Drug (ID: DMQXUYH)

Drug Name
SD-208 Drug Info
Synonyms SCI-208
Cross-matching ID
PubChem CID
10316032
ChEBI ID
CHEMBL238125
CAS Number
CAS 627536-09-8
TTD Drug ID
D0V8AC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.32 0.00e+0 113/158 (71.52%) MRPL9;MRPL3;MRPS2;...
Ribosome biogenesis in eukaryotes 2.20 0.00e+0 52/108 (48.15%) IMP4;FBL;HEATR1;...
Spliceosome 2.07 0.00e+0 101/150 (67.33%) HSPA1A;LSM5;SF3B5;...
DNA replication 2.06 0.00e+0 34/36 (94.44%) PCNA;POLE3;RFC3;...
Valine, leucine and isoleucine degradation 2.05 0.00e+0 42/48 (87.5%) PCCB;ACAT1;ACAA1;...
Propanoate metabolism 2.02 0.00e+0 30/34 (88.24%) PCCB;ACAT1;ABAT;...
Protein export 1.98 2.30e-3 17/23 (73.91%) OXA1L;SRPRB;SEC63;...
Glyoxylate and dicarboxylate metabolism 1.92 4.02e-3 23/30 (76.67%) PCCB;ACAT1;MDH2;...
Pentose and glucuronate interconversions 1.91 3.58e-3 17/34 (50%) AKR1B10;UGT2B28;DCXR;...
Mismatch repair 1.87 5.63e-3 22/23 (95.65%) PCNA;RFC3;MLH1;...
Fatty acid degradation 1.87 5.12e-3 40/43 (93.02%) ACAT1;ACAA1;ADH1B;...
Arginine biosynthesis 1.83 6.70e-3 17/22 (77.27%) CPS1;GLUD1;ARG1;...
Folate biosynthesis 1.82 6.81e-3 23/26 (88.46%) AKR1B10;AKR1C3;ALPL;...
RNA transport 1.81 6.32e-3 128/186 (68.82%) PRMT5;PABPC4;EIF1AY;...
Porphyrin and chlorophyll metabolism 1.78 9.65e-3 23/43 (53.49%) UGT2B28;COX15;UGT2B15;...
RNA polymerase 1.77 9.05e-3 23/31 (74.19%) POLR2D;POLR1D;POLR2L;...
Alanine, aspartate and glutamate metabolism 1.77 8.99e-3 27/37 (72.97%) CPS1;ABAT;GLUD1;...
Glycine, serine and threonine metabolism 1.75 9.38e-3 31/40 (77.5%) CBS;GLDC;AMT;...
Cysteine and methionine metabolism 1.73 1.06e-2 43/50 (86%) SRM;CBS;MDH2;...
Drug metabolism 1.72 1.09e-2 78/151 (51.66%) UGT2B28;NME4;ALDH3A1;...
Retinol metabolism 1.67 1.72e-2 41/68 (60.29%) ALDH1A1;UGT2B28;ADH1B;...
beta-Alanine metabolism 1.66 1.83e-2 25/30 (83.33%) ABAT;ALDH3A1;CNDP2;...
Steroid hormone biosynthesis 1.64 1.99e-2 43/61 (70.49%) AKR1C3;AKR1C1;UGT2B28;...
Proximal tubule bicarbonate reclamation 1.61 2.48e-2 21/23 (91.3%) AQP1;PCK1;GLUD1;...
Citrate cycle (TCA cycle) 1.61 2.41e-2 30/30 (100%) PCK1;IDH2;MDH2;...
Thermogenesis 1.58 3.25e-2 173/232 (74.57%) CYC1;ATP5MC3;NDUFS1;...
Caffeine metabolism 1.58 3.37e-2 5/6 (83.33%) CYP1A2;NAT1;NAT2;...
Metabolism of xenobiotics by cytochrome P450 1.57 3.56e-2 49/77 (63.64%) AKR1C1;UGT2B28;ALDH3A1;...
One carbon pool by folate 1.54 4.11e-2 15/20 (75%) MTHFD1;ALDH1L1;AMT;...
Fanconi anemia pathway 1.54 4.21e-2 36/54 (66.67%) REV3L;CENPX;REV1;...
Gastric acid secretion -1.61 4.77e-2 63/76 (82.89%) KCNQ1;ACTB;MYLK;...
Rheumatoid arthritis -1.61 4.93e-2 78/93 (83.87%) ATP6V1B2;MMP3;ANGPT1;...
Other types of O-glycan biosynthesis -1.62 4.92e-2 29/47 (61.7%) COLGALT2;C1GALT1;POMT1;...
PI3K-Akt signaling pathway -1.64 4.43e-2 317/354 (89.55%) FGF1;RPS6KB1;IGF1R;...
Synaptic vesicle cycle -1.64 4.43e-2 63/78 (80.77%) SLC6A4;DNM2;ATP6V1B2;...
Small cell lung cancer -1.64 4.52e-2 90/92 (97.83%) TRAF1;PIK3CD;CDKN2B;...
Long-term potentiation -1.66 3.44e-2 61/67 (91.04%) RAP1A;RPS6KA3;ITPR2;...
Insulin secretion -1.67 3.54e-2 75/86 (87.21%) ATP1B3;ATP1A3;CREB3L1;...
Amino sugar and nucleotide sugar metabolism -1.67 3.66e-2 38/48 (79.17%) HKDC1;HK1;GALE;...
Central carbon metabolism in cancer -1.68 3.67e-2 67/70 (95.71%) PFKL;SLC1A5;G6PD;...
Axon guidance -1.68 3.86e-2 151/182 (82.97%) RAC1;SLIT2;BMP7;...
Hypertrophic cardiomyopathy -1.72 2.38e-2 81/90 (90%) CACNA1F;CACNA2D1;EDN1;...
Dilated cardiomyopathy -1.72 2.53e-2 86/96 (89.58%) TTN;CACNB2;CACNG2;...
Salivary secretion -1.74 2.40e-2 76/93 (81.72%) AQP5;ITPR2;MUC5B;...
TGF-beta signaling pathway -1.75 2.56e-2 81/94 (86.17%) CDKN2B;FMOD;RPS6KB1;...
HIF-1 signaling pathway -1.76 2.42e-2 105/109 (96.33%) ANGPT1;ALDOA;PIK3CD;...
Carbohydrate digestion and absorption -1.79 1.65e-2 37/47 (78.72%) LCT;G6PC3;AKT3;...
Protein digestion and absorption -1.79 1.79e-2 78/103 (75.73%) ACE2;SLC7A7;COL17A1;...
Phagosome -1.80 1.64e-2 118/152 (77.63%) HLA-F;ATP6V1B2;CLEC7A;...
Bacterial invasion of epithelial cells -1.81 1.13e-2 59/77 (76.62%) CAV3;RAC1;SHC1;...
Human papillomavirus infection -1.82 1.13e-2 284/331 (85.8%) MAPK3;DLG1;ATP6V1A;...
Mucin type O-glycan biosynthesis -1.96 4.24e-3 20/36 (55.56%) GALNT1;GALNT10;GALNT6;...
Lysosome -1.96 4.84e-3 115/128 (89.84%) AP1G2;CTSF;AP3B1;...
Regulation of actin cytoskeleton -1.97 5.65e-3 185/218 (84.86%) ACTB;PIK3CD;MYLK;...
Arrhythmogenic right ventricular cardiomyopathy -1.97 6.78e-3 70/77 (90.91%) JUP;CACNA1F;CACNA2D1;...
Proteoglycans in cancer -2.01 8.47e-3 172/205 (83.9%) ACTB;PIK3CD;TLR4;...
Focal adhesion -2.09 3.77e-3 180/201 (89.55%) ACTB;RAP1A;PIK3CD;...
Steroid biosynthesis -2.15 5.65e-3 19/20 (95%) CYP27B1;HSD17B7;SOAT1;...
ECM-receptor interaction -2.36 0.00e+0 80/88 (90.91%) GP1BB;ITGA5;LAMB2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H