Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMR2790)

Drug Name
Diphencyprone Drug Info
Synonyms
Diphenylcyclopropenone; 886-38-4; Diphencyprone; 2,3-Diphenylcycloprop-2-en-1-one; 2,3-Diphenylcyclopropenone; 2,3-Diphenylcycloprop-2-enone; Cyclopropenone, diphenyl-; DPCP; 2-Cyclopropen-1-one, 2,3-diphenyl-; 1,2-Diphenylcyclopropen-3-one; Cyclopropenone, 2,3-diphenyl-; UNII-I7G14NW5EC; 2,3-Diphenyl-2-cyclopropen-1-one; CHEBI:53074; EINECS 212-948-4; NSC 57541; I7G14NW5EC; Diphenylcyclopropenone, 98%; diphenylcycloprop-2-en-1-one; HCIBTBXNLVOFER-UHFFFAOYSA-N; GEO-01240; MFCD00001311; NCGC00166113-01; CPD000449319
Cross-matching ID
PubChem CID
65057
ChEBI ID
CHEMBL53074
CAS Number
CAS 886-38-4
TTD Drug ID
D02XXT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Legionellosis 2.04 1.32e-2 51/57 (89.47%) CXCL8;HSPA1A;HSPA2;...
TNF signaling pathway 2.02 6.62e-3 103/112 (91.96%) ATF4;CXCL1;IRF1;...
Protein processing in endoplasmic reticulum 1.99 1.76e-2 127/171 (74.27%) DNAJB1;HSPH1;HSPA1A;...
Longevity regulating pathway 1.92 1.65e-2 90/151 (59.6%) HSPA1A;ATF4;HSPA2;...
Viral protein interaction with cytokine and cytokine re... 1.88 3.18e-2 84/100 (84%) CXCL8;CXCL1;ACKR3;...
Lipid and atherosclerosis 1.87 2.65e-2 190/215 (88.37%) CXCL8;HSPA1A;ATF4;...
Cytokine-cytokine receptor interaction 1.80 3.02e-2 246/295 (83.39%) CXCL8;CXCL1;IL11;...
Autophagy 1.79 2.98e-2 113/169 (66.86%) SQSTM1;DDIT4;LAMP2;...
IL-17 signaling pathway 1.70 4.81e-2 84/94 (89.36%) CXCL8;S100A9;CXCL1;...
Mismatch repair -1.78 4.27e-2 22/23 (95.65%) POLD3;MLH3;MSH2;...
N-Glycan biosynthesis -2.05 3.05e-3 38/50 (76%) DDOST;DPAGT1;MAN1C1;...
DNA replication -2.15 6.10e-3 34/36 (94.44%) POLD3;RNASEH1;MCM2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H