Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMR2EUV)

• Drug Name: V-102862 Drug Info
• Synonyms: CO 102862; UNII-0KN11H90GF; 181144-66-1; V-102862; CHEMBL287833; 0KN11H90GF; 4-(4-fluorophenoxy)benzaldehyde semicarbazone; (E)-2-(4-(4-fluorophenoxy)benz-ylidene)hydrazinecarboxamide; V102862; 2-(4-(4-Fluorophenoxy)benzylidene)hydrazinecarboxamide; 2-((4-(4-Fluorophenoxy)phenyl)methylene)hydrazinecarboxamide; CO-102862; 2-[[4-(4-Fluorophenoxy)phenyl]methylene]hydrazinecarboxamide; Hydrazinecarboxamide, 2-((4-(4-fluorophenoxy)phenyl)methylene)-; CHEBI:92156; MolPort-022-863-701; BDBM50141073; AKOS016004881; NCGC00167807-01
• Cross-matching ID:
  PubChem CID: 9816959
  ChEBI ID: CHEMBL287833
  CAS Number: CAS 181144-66-1
  TTD Drug ID: D07EQF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Oxidative phosphorylation	2.15	1.04e-2	93/133 (69.92%)	ATP5MC2;NDUFV2;NDUFC1;...
Glyoxylate and dicarboxylate metabolism	2.12	5.21e-3	23/30 (76.67%)	DLD;GLUL;PCCB;...
Neutrophil extracellular trap formation	1.78	4.38e-2	101/189 (53.44%)	SRC;TLR4;CYBB;...
Propanoate metabolism	1.78	3.65e-2	30/34 (88.24%)	DLD;PCCB;PCCA;...
Type I diabetes mellitus	1.76	3.72e-2	38/43 (88.37%)	HLA-DRA;HLA-DRB1;ICA1;...
Thermogenesis	1.73	4.30e-2	173/232 (74.57%)	KDM3A;ATP5MC2;NDUFV2;...
Platelet activation	1.72	4.52e-2	106/124 (85.48%)	LYN;COL1A2;SRC;...
Linoleic acid metabolism	-1.70	4.40e-2	21/29 (72.41%)	ALOX15;PLA2G2D;PLA2G2E;...
Pantothenate and CoA biosynthesis	-1.71	4.57e-2	14/21 (66.67%)	COASY;ALDH1B1;PANK2;...
TNF signaling pathway	-1.71	4.90e-2	103/112 (91.96%)	MAP2K1;CREB3;MMP3;...
Type II diabetes mellitus	-1.75	4.30e-2	42/46 (91.3%)	IRS2;SOCS1;ADIPOQ;...
Viral protein interaction with cytokine and cytokine re...	-1.78	4.59e-2	84/100 (84%)	CCL2;TNFRSF1A;CXCL11;...
ECM-receptor interaction	-1.87	2.87e-2	80/88 (90.91%)	ITGA10;COL4A5;ITGA7;...
Ribosome biogenesis in eukaryotes	-2.10	0.00e+0	52/108 (48.15%)	CSNK2B;TBL3;FBL;...
Mineral absorption	-2.19	0.00e+0	48/60 (80%)	HMOX1;MT2A;SLC30A1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 10uM	24H	Show ▼