General Information of Drug (ID: DMR2SEB)

Drug Name
BIIE0246 Drug Info
Synonyms BIIE 0246; BIIE-0246
Cross-matching ID
PubChem CID
5311024
CAS Number
CAS 246146-55-4
TTD Drug ID
D06GFZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Alanine, aspartate and glutamate metabolism 2.15 0.00e+0 27/37 (72.97%) ASS1;GLUD1;GLUD2;...
Arginine biosynthesis 1.80 4.45e-2 17/22 (77.27%) ASS1;GLUD1;GLUD2;...
Synthesis and degradation of ketone bodies 1.77 4.22e-2 9/10 (90%) HMGCS1;ACAT1;HMGCS2
Cytokine-cytokine receptor interaction -1.72 3.82e-2 246/295 (83.39%) IL33;TNF;IL17B;...
Epithelial cell signaling in Helicobacter pylori infect... -1.74 2.86e-2 62/70 (88.57%) ATP6V1B2;PTPRZ1;CDC42;...
NOD-like receptor signaling pathway -1.74 3.11e-2 145/181 (80.11%) DNM1L;BCL2L1;ATG5;...
IL-17 signaling pathway -1.80 1.14e-2 84/94 (89.36%) CASP3;TNF;IL17B;...
Collecting duct acid secretion -1.80 1.18e-2 22/27 (81.48%) ATP6V1B2;ATP6V1C1;ATP6V1G1;...
Legionellosis -1.88 3.55e-3 51/57 (89.47%) CASP3;TNF;BNIP3;...
Amoebiasis -2.00 2.22e-3 99/102 (97.06%) SERPINB4;COL4A2;LAMB4;...
Rheumatoid arthritis -2.00 2.96e-3 78/93 (83.87%) TNFRSF11A;IL6;ATP6V0C;...
TNF signaling pathway -2.02 4.44e-3 103/112 (91.96%) CSF2;TNFRSF1B;CREB5;...
Proteasome -2.21 0.00e+0 44/46 (95.65%) PSME2;PSMA2;PSMD1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
SK-N-SH CVCL_0531 Homo sapiens 0.04uM - 10uM 24H