Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMR3S9B)

• Drug Name: Tyloxapol Drug Info
• Synonyms: Alevaire; Enuclene; Macrocyclon; Oxirane; Superinone; Superiuone; Tiloxapol; Tyloxapolum; Tyloxypal; Component of Alevaire; Superiuone [French]; Triton WR 1339; P-Isooctylpolyoxyethylenephenol formaldehyde polymer; Tiloxapol [INN-Spanish]; Triton A-20; Triton WR-1339; Tyloxapolum [INN-Latin]; Oxyethylated tertiary octyl-phenol-formaldehyde polymer; Triton W.R.1339; Tyloxapol [USAN:BAN:INN]; Ethylene oxide-formaldehyde-p-octylphenol copolymer; P-(1,1,3,3-Tetramethylbutyl)phenol polymer with ethylene oxide and formaldehyde; Formaldehyde, polymer with oxirane and 4-(1,1,3,3-tetra methylbutyl)phenol; Formaldehyde, polymer with oxirane and 4-(1,1,3,3-tetramethylbutyl)phenol; Phenol, 4-(1,1,3,3-tetramethylbutyl)-, polymer with formaldehyde and oxirane; Phenol, p-(1,1,3,3-tetramethylbutyl)-, polymer with ethylene oxide and formaldehyde; 4-(1,1,3,3-Tetramethylbutyl)phenol, polymer with formaldehyde & oxirane; 4-(1,1,3,3-Tetramethylbutyl)phenol, polymer with formaldehyde oxirane; 4-(1,1,3,3-tetramethylbutyl)phenol; 4-(2,4,4-trimethylpentan-2-yl)phenol
• Cross-matching ID:
  PubChem CID: 71388
  ChEBI ID: CHEMBL141517
  CAS Number: CAS 25301-02-4
  TTD Drug ID: D00ARN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.04	2.39e-2	19/20 (95%)	MSMO1;SC5D;SQLE;...
Fructose and mannose metabolism	1.88	1.79e-2	30/33 (90.91%)	PFKL;AKR1B10;AKR1B1;...
Basal transcription factors	-1.71	1.92e-2	37/45 (82.22%)	GTF2I;TAF4B;GTF2E1;...
Homologous recombination	-1.76	8.37e-3	35/41 (85.37%)	RAD51B;TOP3A;RPA2;...
RNA transport	-1.77	8.56e-3	128/186 (68.82%)	SEH1L;POP4;FXR2;...
Fanconi anemia pathway	-1.81	9.78e-3	36/54 (66.67%)	CENPX;FANCC;USP1;...
Cell cycle	-1.84	9.13e-3	110/124 (88.71%)	ATM;MCM3;RBL1;...
Proteasome	-1.85	6.85e-3	44/46 (95.65%)	PSMA7;PSMB3;PSMA5;...
Ribosome biogenesis in eukaryotes	-2.01	1.71e-3	52/108 (48.15%)	REXO5;PWP2;HEATR1;...
Mismatch repair	-2.02	2.28e-3	22/23 (95.65%)	RPA2;LIG1;MSH2;...
Nucleotide excision repair	-2.05	0.00e+0	40/47 (85.11%)	POLE;RPA2;LIG1;...
DNA replication	-2.43	0.00e+0	34/36 (94.44%)	RNASEH2B;POLE;RPA2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲