Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMR7H2V)

Drug Name
PRX-08066 Drug Info
Synonyms
PRX-08066; 866206-54-4; PRX-08066 free base; UNII-82SK298EBU; PRX 08066; CHEMBL513994; 82SK298EBU; 5-((4-(6-chlorothieno[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl)methyl)-2-fluorobenzonitrile; SCHEMBL1604039; DTXSID60235710; IENZFHBNCRQMNP-UHFFFAOYSA-N; BCP14768; BDBM50249180; ZINC40403513; AKOS030526950; QC-5875; CS-0991; SB16508; 5-((4-(6-Chlorothieno(2,3-d)pyrimidine-4-ylamino)piperidin-1-yl)methyl)-2-fluorobenzonitrile; PRX 08066;PRX08066; NCGC00386238-02; AK548029; HY-15472; Benzonitrile, 5-((4-((6-chlorothieno(2,3-d)pyrimidi
Cross-matching ID
PubChem CID
11502243
ChEBI ID
CHEMBL513994
CAS Number
CAS 866206-54-4
TTD Drug ID
D0W4XY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Metabolism of xenobiotics by cytochrome P450 -1.70 4.20e-2 49/77 (63.64%) GSTT1;AKR1C1;GSTA4;...
ECM-receptor interaction -1.70 4.44e-2 80/88 (90.91%) SV2A;CHAD;LAMA3;...
IL-17 signaling pathway -1.71 4.26e-2 84/94 (89.36%) MMP13;MAPK8;MAPK1;...
Glycolysis / Gluconeogenesis -1.72 4.64e-2 56/67 (83.58%) ADH1A;PFKL;PGAM1;...
NF-kappa B signaling pathway -1.73 4.22e-2 90/104 (86.54%) DDX58;NFKBIA;MALT1;...
Staphylococcus aureus infection -1.74 4.32e-2 72/95 (75.79%) HLA-DPB1;CFH;KRT20;...
Estrogen signaling pathway -1.81 1.94e-2 119/137 (86.86%) NRAS;CALML4;GNAS;...
Retinol metabolism -1.82 1.75e-2 41/68 (60.29%) CYP2A6;CYP26A1;RETSAT;...
Pertussis -1.85 1.11e-2 64/76 (84.21%) IL23A;PYCARD;TLR4;...
Primary bile acid biosynthesis -1.87 1.33e-2 15/17 (88.24%) AKR1D1;ACOT8;CYP7A1;...
Ribosome -1.91 5.55e-3 113/158 (71.52%) RPL3L;RPL37A;RPL10L;...
Phototransduction -1.98 0.00e+0 21/29 (72.41%) CALML4;PDE6G;CALML5;...
Coronavirus disease -2.03 0.00e+0 215/232 (92.67%) IFNB1;C8A;RPL3L;...
Complement and coagulation cascades -2.15 0.00e+0 76/85 (89.41%) F7;F13A1;SERPINA1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H