Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMR7IVC)

Drug Name
Pimavanserin Drug Info
Synonyms ST51054136; AC-5273; I14-1981; 1-[(4-fluorophenyl)methyl]-1-(1-methyl-4-piperidyl)-3-[[4-(2-methylpropoxy)phenyl]methyl]urea
Cross-matching ID
PubChem CID
10071196
ChEBI ID
CHEMBL2111101
CAS Number
CAS 706779-91-1
TTD Drug ID
D0J8JP
ACDINA Drug ID
D00531

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Amphetamine addiction -1.63 3.68e-2 57/69 (82.61%) CALML4;TH;CREB1;...
Proteasome -1.66 3.68e-2 44/46 (95.65%) PSMC6;PSMD12;PSMC1;...
Kaposi sarcoma-associated herpesvirus infection -1.67 3.57e-2 172/193 (89.12%) PIK3CG;CDK4;IFNA17;...
Legionellosis -1.67 3.51e-2 51/57 (89.47%) HSPA1L;RAB1A;CASP7;...
Cell adhesion molecules -1.68 3.15e-2 118/148 (79.73%) HLA-E;SELP;CLDN1;...
Fluid shear stress and atherosclerosis -1.70 2.54e-2 123/139 (88.49%) MAPK8;RELA;NQO1;...
Pertussis -1.70 2.54e-2 64/76 (84.21%) MAPK14;CALML4;CXCL6;...
NF-kappa B signaling pathway -1.72 2.09e-2 90/104 (86.54%) CXCL1;DDX58;BLNK;...
Prion disease -1.74 1.71e-2 209/273 (76.56%) KIF5A;CAV2;CASP9;...
Leishmaniasis -1.75 1.79e-2 67/77 (87.01%) MAPK14;HLA-DOA;MARCKSL1;...
Viral myocarditis -1.77 1.49e-2 53/60 (88.33%) HLA-E;CAV1;HLA-F;...
Epithelial cell signaling in Helicobacter pylori infect... -1.78 1.57e-2 62/70 (88.57%) PLCG2;CXCR1;MAPK14;...
Lipid and atherosclerosis -1.79 1.30e-2 190/215 (88.37%) IFNA17;PLCB4;CASP6;...
Nitrogen metabolism -1.81 1.22e-2 16/17 (94.12%) CA9;CA14;GLUD1;...
Protein export -1.82 1.05e-2 17/23 (73.91%) SEC61B;SRP72;SEC62;...
Systemic lupus erythematosus -1.84 9.52e-3 45/135 (33.33%) SNRPB;C7;HLA-DRA;...
Rheumatoid arthritis -1.86 7.42e-3 78/93 (83.87%) HLA-DOA;CXCL6;TNFSF11;...
Metabolism of xenobiotics by cytochrome P450 -1.88 7.99e-3 49/77 (63.64%) CYP1A1;CBR3;SULT2A1;...
IL-17 signaling pathway -1.88 8.66e-3 84/94 (89.36%) CCL11;CXCL1;CCL17;...
Coronavirus disease -1.90 7.08e-3 215/232 (92.67%) NLRP3;RPS9;RPL36AL;...
Viral protein interaction with cytokine and cytokine re... -1.91 6.49e-3 84/100 (84%) CCL11;CCL24;CXCL1;...
Parkinson disease -1.94 2.89e-3 176/249 (70.68%) NDUFB6;PSMD12;PSMC1;...
TNF signaling pathway -1.95 3.25e-3 103/112 (91.96%) CSF2;ITCH;MAPK14;...
Graft-versus-host disease -1.96 3.71e-3 32/42 (76.19%) CD28;IL1B;HLA-DQB1;...
Tyrosine metabolism -1.97 4.33e-3 30/36 (83.33%) AOX1;TYR;ADH1A;...
Autoimmune thyroid disease -2.00 2.60e-3 46/53 (86.79%) CD28;HLA-DQB1;HLA-DMB;...
Staphylococcus aureus infection -2.03 3.25e-3 72/95 (75.79%) FPR3;KRT23;KRT10;...
Allograft rejection -2.03 4.33e-3 32/38 (84.21%) HLA-DOA;HLA-G;HLA-C;...
Type I diabetes mellitus -2.15 6.49e-3 38/43 (88.37%) GAD2;HLA-DOA;HLA-G;...
Antigen processing and presentation -2.26 1.30e-2 60/78 (76.92%) PSME2;CD8A;NFYB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H