Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRA736)

Drug Name
SACCHARIN Drug Info
Synonyms
saccharin; 81-07-2; o-Sulfobenzimide; Saccharine; o-Benzoic sulfimide; Saccharimide; Benzosulfimide; o-Benzosulfimide; Benzoic sulfimide; Benzosulphimide; Saccharinose; Garantose; Saccharinol; Gluside; Saccharin acid; Benzosulfinide; Hermesetas; Saccharol; Sweeta; Saccharin insoluble; Glucid; Benzoic sulphimide; 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide; Saccharina; Zaharina; Sucrette; Sacarina; Kandiset; Sykose; Saxin; o-Benzoyl sulfimide; Benzo-2-sulphimide; Sucre edulcor; o-Benzoic sulphimide; Benzoylsulfonic Imide; o-Sulfobenzoic acid im
Cross-matching ID
PubChem CID
5143
ChEBI ID
CHEMBL310671
CAS Number
CAS 128-44-9
TTD Drug ID
D0A0YX
VARIDT Drug ID
DR00801

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption 2.13 0.00e+0 48/60 (80%) TF;SLC26A3;MT1M;...
DNA replication 2.08 0.00e+0 34/36 (94.44%) PCNA;PRIM1;POLE3;...
Proteasome 1.98 7.20e-3 44/46 (95.65%) PSMB7;PSMB1;PSMD8;...
Pyrimidine metabolism 1.87 1.35e-2 40/56 (71.43%) NT5E;ENPP1;RRM2;...
Ribosome 1.82 2.16e-2 113/158 (71.52%) RPS5;RPL36;RPL29;...
Nitrogen metabolism 1.81 1.80e-2 16/17 (94.12%) CA2;CA4;GLUL;...
Histidine metabolism -1.74 4.64e-2 16/22 (72.73%) ALDH1B1;HNMT;ALDH3B1;...
Glycolysis / Gluconeogenesis -1.86 2.78e-2 56/67 (83.58%) ADH1C;ALDH1B1;ADPGK;...
Valine, leucine and isoleucine degradation -2.07 9.28e-3 42/48 (87.5%) BCAT2;MMUT;HADHB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.08uM - 20uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.08uM - 20uM 24H