Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRADBU)

• Drug Name: SK&F-104078 Drug Info
• Synonyms: SK-104078
• Cross-matching ID:
  PubChem CID: 122295
  ChEBI ID: CHEMBL114166
  CAS Number: CAS 110857-22-2
  TTD Drug ID: D08OWQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Neutrophil extracellular trap formation	1.96	2.36e-2	101/189 (53.44%)	TLR4;PRKCA;AZU1;...
Viral protein interaction with cytokine and cytokine re...	1.86	2.36e-2	84/100 (84%)	TNFSF10;CCR1;CCL4;...
Primary immunodeficiency	1.85	2.36e-2	33/38 (86.84%)	IGLL1;RAG1;IL7R;...
Graft-versus-host disease	1.76	4.95e-2	32/42 (76.19%)	PRF1;CD86;GZMB;...
Natural killer cell mediated cytotoxicity	1.75	4.32e-2	99/131 (75.57%)	TNFSF10;PRKCA;PRF1;...
Cytokine-cytokine receptor interaction	1.75	3.70e-2	246/295 (83.39%)	TNFSF10;TNFRSF11B;CCR1;...
Malaria	1.75	3.39e-2	44/50 (88%)	TLR4;SDC2;HBB;...
NF-kappa B signaling pathway	1.75	3.14e-2	90/104 (86.54%)	TLR4;NFKB2;BCL2A1;...
Fat digestion and absorption	-1.80	2.71e-2	35/43 (81.4%)	PLA2G10;PNLIPRP2;ABCA1;...
Thermogenesis	-1.81	3.34e-2	173/232 (74.57%)	ATP5MC2;PRKAB2;ACSL3;...
Parkinson disease	-1.95	1.67e-2	176/249 (70.68%)	NDUFA9;CAMK2A;PSMB1;...
Oxidative phosphorylation	-2.02	8.35e-3	93/133 (69.92%)	ATP5PF;ATP5MC2;ATP6V0A2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Hide ▲