Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRF9YK)

Drug Name
Empagliflozin Drug Info
Synonyms
864070-44-0; JARDIANCE; BI 10773; UNII-HDC1R2M35U; Empagliflozin (BI 10773); BI-10773; BI10773; HDC1R2M35U; CHEBI:82720; 1-chloro-4-(glucopyranos-1-yl)-2-(4-(tetrahydrofuran-3-yloxy)benzyl)benzene; AK160980; (1S)-1,5-anhydro-1-(4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl)-D-glucitol; (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Cross-matching ID
PubChem CID
11949646
ChEBI ID
CHEMBL2107830
CAS Number
CAS 864070-44-0
TTD Drug ID
D06ALD
VARIDT Drug ID
DR00271
INTEDE Drug ID
DR1755
ACDINA Drug ID
D01043

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Pentose phosphate pathway 2.17 0.00e+0 25/30 (83.33%) GPI;TKT;ALDOC;...
Citrate cycle (TCA cycle) 2.14 6.49e-3 30/30 (100%) DLD;DLST;IDH2;...
Glycolysis / Gluconeogenesis 2.11 4.33e-3 56/67 (83.58%) PGAM1;GPI;PKM;...
Progesterone-mediated oocyte maturation 2.00 6.49e-3 75/100 (75%) CCNB1;ADCY1;HSP90AA1;...
Mismatch repair 1.96 7.79e-3 22/23 (95.65%) PCNA;RFC3;MLH1;...
Central carbon metabolism in cancer 1.95 6.49e-3 67/70 (95.71%) PGAM1;PKM;FGFR2;...
Fructose and mannose metabolism 1.91 1.48e-2 30/33 (90.91%) PMM2;PFKFB3;ALDOC;...
DNA replication 1.90 1.46e-2 34/36 (94.44%) PCNA;RFC3;MCM4;...
p53 signaling pathway 1.87 1.59e-2 63/73 (86.3%) CCNB1;RRM2;CHEK1;...
Basal cell carcinoma 1.83 1.82e-2 41/63 (65.08%) BMP4;LEF1;PTCH1;...
Cell cycle 1.75 3.19e-2 110/124 (88.71%) CCNB1;E2F2;SMC1A;...
Prion disease 1.74 3.46e-2 209/273 (76.56%) TUBB2A;CREB1;HSPA8;...
HIF-1 signaling pathway 1.74 3.19e-2 105/109 (96.33%) MKNK2;SLC2A1;PFKFB3;...
Carbohydrate digestion and absorption 1.73 3.24e-2 37/47 (78.72%) SLC2A5;PLCB1;ATP1A1;...
Melanogenesis 1.70 3.89e-2 74/101 (73.27%) LEF1;CREB1;ADCY1;...
Prostate cancer 1.70 4.06e-2 93/97 (95.88%) LEF1;E2F2;CREB1;...
Neomycin, kanamycin and gentamicin biosynthesis 1.70 4.05e-2 5/5 (100%) HK3;HK2;HK1
Steroid biosynthesis -1.93 3.35e-3 19/20 (95%) CYP51A1;DHCR7;SOAT1;...
Nicotinate and nicotinamide metabolism -1.98 6.70e-3 25/35 (71.43%) NMRK1;NADSYN1;NT5C;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 3.33uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 3.33uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 3.33uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 3.33uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 3.33uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 3.33uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 3.33uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 3.33uM - 10uM 24H