Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRFWGK)

• Drug Name: Novobiocin Drug Info
• Synonyms: Albamix; Albamycin; Cardelmycin; Cathocin; Cathomycin; Inamycin; NOV; Novobiocina; Novobiocine; Novobiocinum; Robiocina; Sirbiocina; Spheromycin; Stilbiocina; Streptonivicin; Crystallinic acid; Novobiocin sodium salt; PA 93; U 6391; Albamycin (TN); Antibiotic PA-93; Novo-R; Novobiocin [INN:BAN]; Novobiocina [INN-Spanish]; Novobiocine [INN-French]; Novobiocinum [INN-Latin]; Streptonivicin (*Sodium salt*); [(3R,4S,5R,6R)-5-hydroxy-6-[2-hydroxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-8-methyl-4-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] carbamate; N-[7-[[3-O-(Aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-.beta.-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl); (3R,4S,5R,6R)-5-hydroxy-6-{[4-hydroxy-3-({[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]carbonyl}amino)-8-methyl-2-oxo-2H-chromen-7-yl]oxy}-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate; (3r,4s,5r,6r)-5-hydroxy-6-[(2-hydroxy-3-{[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzoyl]amino}-8-methyl-4-oxo-4h-chromen-7-yl)oxy]-3-methoxy-2,2-dimethyltetrahydro-2h-pyran-4-yl carbamate(non-preferred name); 7-(3-(O-Carbamoyl)-4-(O-methyl)-5,5-dimethyl-alpha-L-lyxopyranosyloxy)-4-hydroxy-3-(4-hydroxy-3-(3-methyl-2-butenyl)benzamidol)-8-methylcumarin; 7-(Carbamoyltetrahydro-3-hydroxy-5-methoxy-6,6-dimethylpyran-2-yloxy)-4-hydroxy-3-(4-hydroxy-3-(3-methylbut-2-enyl)benzamide)-8-methyl-2H-chromen-2-one
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 54675769
  ChEBI ID: CHEMBL36506
  CAS Number: CAS 303-81-1
  TTD Drug ID: D0Q0PR
  VARIDT Drug ID: DR00660

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.09	0.00e+0	34/36 (94.44%)	PCNA;MCM6;POLE2;...
Ribosome biogenesis in eukaryotes	1.86	2.92e-2	52/108 (48.15%)	NVL;NXT2;NMD3;...
Citrate cycle (TCA cycle)	1.82	4.87e-2	30/30 (100%)	DLD;DLAT;SDHC;...
Nitrogen metabolism	1.81	3.65e-2	16/17 (94.12%)	CA12;CA2;CA4;...
Th17 cell differentiation	-1.67	4.62e-2	95/107 (88.79%)	HLA-DQB1;HLA-DPB1;STAT5A;...
Measles	-1.69	4.26e-2	133/139 (95.68%)	FADD;CCNE2;STAT5A;...
Viral protein interaction with cytokine and cytokine re...	-1.72	3.46e-2	84/100 (84%)	CCR1;IL18;CXCR2;...
Legionellosis	-1.73	3.62e-2	51/57 (89.47%)	NFKBIA;IL1B;HSPA6;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.74	3.31e-2	62/70 (88.57%)	ATP6V1G1;ATP6V0E1;IKBKB;...
Vibrio cholerae infection	-1.78	2.33e-2	44/50 (88%)	ERO1A;KDELR3;ATP6V1G1;...
T cell receptor signaling pathway	-1.80	1.53e-2	93/104 (89.42%)	KRAS;PAK1;CSF2;...
NF-kappa B signaling pathway	-1.83	1.22e-2	90/104 (86.54%)	CARD10;CD40LG;CSNK2B;...
PD-L1 expression and PD-1 checkpoint pathway in cancer	-1.86	1.02e-2	79/89 (88.76%)	CD3D;PIK3R3;CSNK2B;...
Rheumatoid arthritis	-2.00	3.40e-3	78/93 (83.87%)	HLA-DMB;ATP6V1G1;ACP5;...
Mineral absorption	-2.00	5.10e-3	48/60 (80%)	SLC39A4;VDR;MT1G;...
IL-17 signaling pathway	-2.03	1.02e-2	84/94 (89.36%)	IKBKB;NFKBIA;IL1B;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.04uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 10uM	24H	Show ▼