Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRH291)

Drug Name
Dexanabinol Drug Info
Synonyms
Sinnabidiol; HU 211; HU-211; PRS 211007-000; (6aS,10aS)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol; 1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol; 1,1-Dimethylheptyl-7-hydroxy-delta(6)-tetrahydrocannabinol; 11-Hydroxy-delta(8)-tetrahydrocannabinol-dimethylheptyl; 11-Hydroxy-delta-8-dmh-thc; 11-Hydroxymethyl-delta(8)-tetrahydrocannabinol-dimethylheptyl; 11-OH-delta(8)-Thc-dmh; 5'(1,1-Dimethylheptyl)-7-hydroxyhexahydrocannabinol; 7-Hydroxy-delta-6-tetrahydrocannabinoldimethylheptyl
Cross-matching ID
PubChem CID
107778
ChEBI ID
CHEMBL334533
CAS Number
CAS 112924-45-5
TTD Drug ID
D0Y9RO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway 2.65 0.00e+0 84/94 (89.36%) CXCL8;PTGS2;MMP1;...
TNF signaling pathway 2.12 0.00e+0 103/112 (91.96%) PTGS2;CEBPB;PIK3CA;...
Kaposi sarcoma-associated herpesvirus infection 2.12 0.00e+0 172/193 (89.12%) CXCL8;PTGS2;HLA-B;...
RIG-I-like receptor signaling pathway 2.07 0.00e+0 64/70 (91.43%) CXCL8;ISG15;DDX58;...
NF-kappa B signaling pathway 2.06 0.00e+0 90/104 (86.54%) CXCL8;PTGS2;PLAU;...
Herpes simplex virus 1 infection 2.05 0.00e+0 165/498 (33.13%) HLA-B;OAS3;OAS2;...
NOD-like receptor signaling pathway 2.01 1.55e-3 145/181 (80.11%) CXCL8;OAS3;OAS2;...
Epstein-Barr virus infection 1.94 4.06e-3 189/202 (93.56%) HLA-B;OAS3;ISG15;...
Measles 1.90 4.81e-3 133/139 (95.68%) OAS3;MX1;OAS2;...
Small cell lung cancer 1.85 7.58e-3 90/92 (97.83%) PTGS2;ITGA6;PIK3CA;...
C-type lectin receptor signaling pathway 1.84 6.89e-3 93/104 (89.42%) PTGS2;EGR2;EGR3;...
Hepatitis C 1.84 6.32e-3 139/157 (88.54%) IFIT1;OAS3;MX1;...
Epithelial cell signaling in Helicobacter pylori infect... 1.79 1.17e-2 62/70 (88.57%) CXCL8;LYN;IKBKB;...
Human cytomegalovirus infection 1.78 1.24e-2 201/225 (89.33%) CXCL8;GNAS;PTGS2;...
Viral protein interaction with cytokine and cytokine re... 1.75 1.66e-2 84/100 (84%) CXCL8;PPBP;CXCL14;...
Protein export 1.75 1.63e-2 17/23 (73.91%) SEC62;SEC61B;SEC61G;...
PPAR signaling pathway 1.69 3.44e-2 66/74 (89.19%) FABP4;CD36;LPL;...
Cytosolic DNA-sensing pathway 1.68 3.61e-2 52/63 (82.54%) DDX58;IL1B;IRF7;...
Prostate cancer 1.66 4.16e-2 93/97 (95.88%) PLAT;PLAU;PIK3CA;...
Toll-like receptor signaling pathway 1.66 3.95e-2 94/104 (90.38%) CXCL8;PIK3CA;IL1B;...
Protein processing in endoplasmic reticulum 1.63 4.95e-2 127/171 (74.27%) HERPUD1;RAD23B;SEC62;...
Human papillomavirus infection 1.63 4.78e-2 284/331 (85.8%) GNAS;PTGS2;ITGA6;...
Cellular senescence 1.63 4.62e-2 139/156 (89.1%) CXCL8;TGFBR2;HLA-B;...
Cytokine-cytokine receptor interaction 1.63 4.47e-2 246/295 (83.39%) CXCL8;GDF15;TGFBR2;...
Mineral absorption 1.63 4.42e-2 48/60 (80%) STEAP1;MT1X;MT1HL1;...
Influenza A 1.63 4.25e-2 156/172 (90.7%) CXCL8;OAS3;MX1;...
Hepatitis B 1.62 4.37e-2 151/162 (93.21%) CXCL8;TGFBR2;EGR2;...
Alanine, aspartate and glutamate metabolism -1.72 4.79e-2 27/37 (72.97%) GLS;AGXT;GLUD1;...
Primary bile acid biosynthesis -1.75 4.68e-2 15/17 (88.24%) CYP39A1;ACOX2;AKR1C4;...
Valine, leucine and isoleucine degradation -1.82 1.99e-2 42/48 (87.5%) ACADSB;HADHA;HADHB;...
Butanoate metabolism -1.85 1.58e-2 23/28 (82.14%) OXCT2;ECHS1;GAD1;...
beta-Alanine metabolism -1.85 2.11e-2 25/30 (83.33%) ACOX1;ALDH1B1;ECHS1;...
Systemic lupus erythematosus -2.01 0.00e+0 45/135 (33.33%) CTSG;HLA-DOA;C8G;...
Drug metabolism -2.13 0.00e+0 78/151 (51.66%) GMPS;NME3;CYP2A6;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H