Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRICNP)

Drug Name
Vandetanib Drug Info
Synonyms
Zactima; Vandetanib [INN]; CH 331; ZD 6474; ZD6474; AZD-6474; CH-331; F9995-0087; ZD-6474; Zactima, ZD6474; Vandetanib (JAN/INN); Vandetanib, Zactima, ZD6474; N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-4-quinazolinamine; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline; Vandetanib (Pan-TK inhibitor)
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
3081361
ChEBI ID
CHEMBL24828
CAS Number
CAS 443913-73-3
TTD Drug ID
D0G6QF
VARIDT Drug ID
DR00618
INTEDE Drug ID
DR1669
ACDINA Drug ID
D00720

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.62 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR24;...
Oxidative phosphorylation 2.21 0.00e+0 93/133 (69.92%) ATP6V1B2;ATP6V1A;ATP6V0D1;...
Terpenoid backbone biosynthesis 2.21 0.00e+0 18/22 (81.82%) HMGCS1;IDI1;ACAT2;...
Biosynthesis of unsaturated fatty acids 2.16 0.00e+0 21/27 (77.78%) SCD;FADS1;ELOVL6;...
PPAR signaling pathway 2.09 0.00e+0 66/74 (89.19%) SCD;HMGCS1;FADS2;...
Steroid hormone biosynthesis 2.07 0.00e+0 43/61 (70.49%) HSD17B7;AKR1C2;CYP1B1;...
Butanoate metabolism 1.93 7.66e-3 23/28 (82.14%) HMGCS1;ACAT2;AACS;...
DNA replication 1.85 1.76e-2 34/36 (94.44%) POLE2;PCNA;MCM6;...
Fatty acid elongation 1.84 1.56e-2 19/27 (70.37%) ELOVL6;TECR;HADH;...
Tryptophan metabolism 1.83 1.41e-2 35/42 (83.33%) ACAT2;CYP1B1;CAT;...
Valine, leucine and isoleucine degradation 1.81 1.46e-2 42/48 (87.5%) HMGCS1;ACAT2;AACS;...
Glutathione metabolism 1.80 1.56e-2 43/57 (75.44%) IDH1;PGD;GSTA4;...
Glyoxylate and dicarboxylate metabolism 1.78 1.80e-2 23/30 (76.67%) ACAT2;CAT;SHMT1;...
Metabolism of xenobiotics by cytochrome P450 1.72 2.97e-2 49/77 (63.64%) CYP1B1;AKR1C1;GSTA4;...
Synthesis and degradation of ketone bodies 1.69 3.84e-2 9/10 (90%) HMGCS1;ACAT2
Pyruvate metabolism 1.67 4.61e-2 41/47 (87.23%) ACAT2;ME1;ACACA;...
Pantothenate and CoA biosynthesis 1.67 4.33e-2 14/21 (66.67%) DPYD;ALDH2;PANK3;...
Fatty acid biosynthesis 1.66 4.13e-2 16/18 (88.89%) FASN;ACSL3;ACSL1;...
Ferroptosis 1.66 4.34e-2 36/41 (87.8%) HMOX1;FTH1;ACSL3;...
Bladder cancer -1.61 4.49e-2 40/41 (97.56%) CXCL8;RASSF1;HRAS;...
Hematopoietic cell lineage -1.63 3.76e-2 90/99 (90.91%) CD22;IL4R;CD3E;...
Colorectal cancer -1.63 3.74e-2 84/86 (97.67%) CASP9;RALGDS;RAC2;...
JAK-STAT signaling pathway -1.64 3.89e-2 146/162 (90.12%) MCL1;CSH1;IL4R;...
Relaxin signaling pathway -1.67 2.54e-2 114/129 (88.37%) PRKACB;TGFBR2;VEGFD;...
Th1 and Th2 cell differentiation -1.68 2.26e-2 80/92 (86.96%) IL13;JAK3;IL12A;...
Inflammatory bowel disease -1.71 2.02e-2 58/65 (89.23%) IL18;MAF;IL2RG;...
Autoimmune thyroid disease -1.73 2.04e-2 46/53 (86.79%) HLA-DOA;TSHB;CD80;...
Ras signaling pathway -1.73 2.07e-2 201/232 (86.64%) FASLG;PDGFB;MRAS;...
Adherens junction -1.74 1.87e-2 63/71 (88.73%) SNAI2;RAC2;FER;...
Allograft rejection -1.74 1.98e-2 32/38 (84.21%) CD28;IL12A;HLA-DOA;...
Arrhythmogenic right ventricular cardiomyopathy -1.75 2.01e-2 70/77 (90.91%) ITGA2;ITGA5;ITGB6;...
Natural killer cell mediated cytotoxicity -1.75 2.14e-2 99/131 (75.57%) PTPN11;PAK1;CD244;...
Viral myocarditis -1.75 2.19e-2 53/60 (88.33%) CD28;ACTB;HLA-DOA;...
Bacterial invasion of epithelial cells -1.77 1.68e-2 59/77 (76.62%) ARHGEF26;CD2AP;ITGA5;...
Amoebiasis -1.78 1.82e-2 99/102 (97.06%) LAMA4;LAMA2;PRKACB;...
Graft-versus-host disease -1.79 1.59e-2 32/42 (76.19%) KIR2DL1;CD28;KIR3DL1;...
PI3K-Akt signaling pathway -1.80 1.75e-2 317/354 (89.55%) MTOR;LAMC1;FASLG;...
Small cell lung cancer -1.80 1.46e-2 90/92 (97.83%) TRAF1;RELA;CDK6;...
AGE-RAGE signaling pathway in diabetic complications -1.84 9.12e-3 97/100 (97%) TGFBR2;VEGFD;COL3A1;...
Dilated cardiomyopathy -1.86 8.34e-3 86/96 (89.58%) ITGA2;ADCY2;ITGA5;...
Hypertrophic cardiomyopathy -1.89 9.73e-3 81/90 (90%) ITGA2;ITGA5;ITGB6;...
ECM-receptor interaction -1.92 8.76e-3 80/88 (90.91%) LAMC1;ITGA2;COL9A3;...
Type I diabetes mellitus -1.93 7.30e-3 38/43 (88.37%) HLA-B;IL1A;HLA-DRB1;...
Proteoglycans in cancer -1.95 4.87e-3 172/205 (83.9%) HCLS1;COL1A2;RHOA;...
Ribosome biogenesis in eukaryotes -2.00 0.00e+0 52/108 (48.15%) LSG1;MDN1;NOL6;...
Focal adhesion -2.26 0.00e+0 180/201 (89.55%) LAMC1;ITGA2;PDGFB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
CJM CVCL_U797 Homo sapiens 0.12uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 10uM 24H