Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRJ7D1)

Drug Name
Nomegestrol acetate Drug Info
Synonyms Lutenyl (TN)
Cross-matching ID
PubChem CID
91668
ChEBI ID
CHEMBL135564
CAS Number
CAS 58652-20-3
TTD Drug ID
D0V2JK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Staphylococcus aureus infection 2.16 0.00e+0 72/95 (75.79%) KRT23;KRT14;C1R;...
Systemic lupus erythematosus 2.04 5.38e-3 45/135 (33.33%) C1R;C3;C1QA;...
Graft-versus-host disease 2.01 7.17e-3 32/42 (76.19%) GZMB;IFNG;HLA-DPA1;...
Allograft rejection 1.99 5.38e-3 32/38 (84.21%) GZMB;IFNG;HLA-DPA1;...
Antigen processing and presentation 1.99 4.30e-3 60/78 (76.92%) HSPA8;CTSS;CALR;...
Intestinal immune network for IgA production 1.92 3.58e-3 38/48 (79.17%) TGFB1;HLA-DPA1;HLA-DRA;...
Leishmaniasis 1.92 3.07e-3 67/77 (87.01%) CYBA;C3;TLR4;...
Proteasome 1.91 2.69e-3 44/46 (95.65%) IFNG;PSMD14;PSMB8;...
Type I diabetes mellitus 1.85 4.78e-3 38/43 (88.37%) PTPRN2;GZMB;IFNG;...
Spliceosome 1.84 4.30e-3 101/150 (67.33%) HSPA8;PUF60;PRPF8;...
Acute myeloid leukemia 1.83 5.87e-3 66/67 (98.51%) BCL2A1;MYC;PIK3R1;...
IL-17 signaling pathway 1.82 7.17e-3 84/94 (89.36%) S100A9;MMP3;CXCL6;...
Herpes simplex virus 1 infection 1.81 7.44e-3 165/498 (33.13%) C3;CALR;IFNG;...
Inflammatory bowel disease 1.79 1.23e-2 58/65 (89.23%) TLR4;TGFB1;IFNG;...
Autoimmune thyroid disease 1.79 1.15e-2 46/53 (86.79%) GZMB;HLA-DPA1;CGA;...
Viral protein interaction with cytokine and cytokine re... 1.77 1.21e-2 84/100 (84%) CXCL13;CXCL6;CCL4;...
Epstein-Barr virus infection 1.74 1.52e-2 189/202 (93.56%) CALR;CD58;HLA-DPA1;...
Toxoplasmosis 1.74 1.43e-2 103/112 (91.96%) HSPA8;TLR4;TGFB1;...
Fructose and mannose metabolism 1.72 1.58e-2 30/33 (90.91%) AKR1B1;PFKFB3;ALDOA;...
Measles 1.72 1.56e-2 133/139 (95.68%) HSPA8;TLR4;TLR2;...
Tuberculosis 1.70 1.84e-2 159/180 (88.33%) CTSS;C3;TLR4;...
Glycolysis / Gluconeogenesis 1.69 1.91e-2 56/67 (83.58%) LDHB;ALDOA;PFKP;...
Th17 cell differentiation 1.69 1.82e-2 95/107 (88.79%) TGFB1;IFNG;HLA-DPA1;...
Human T-cell leukemia virus 1 infection 1.69 1.93e-2 197/219 (89.95%) TGFB1;TSPO;CALR;...
Primary immunodeficiency 1.69 1.85e-2 33/38 (86.84%) IL7R;BTK;PTPRC;...
Galactose metabolism 1.68 1.82e-2 26/31 (83.87%) AKR1B1;PFKP;GLB1;...
Chronic myeloid leukemia 1.68 1.79e-2 72/76 (94.74%) ABL1;TGFB1;MYC;...
Cell cycle 1.67 1.84e-2 110/124 (88.71%) ABL1;TGFB1;MYC;...
Central carbon metabolism in cancer 1.66 2.11e-2 67/70 (95.71%) LDHB;MYC;PIK3R1;...
Glycerolipid metabolism 1.65 2.37e-2 44/61 (72.13%) AKR1B1;MGLL;LPIN1;...
Amphetamine addiction -1.79 4.88e-2 57/69 (82.61%) ATF2;FOS;PPP1CB;...
Selenocompound metabolism -1.82 4.58e-2 11/17 (64.71%) SEPHS2;SEPHS1;CTH;...
Oxidative phosphorylation -2.25 0.00e+0 93/133 (69.92%) ATP6V1F;NDUFS3;NDUFB6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 6.66uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H