Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMRJKIV)

Drug Name
Caffeic acid phenethyl ester Drug Info
Synonyms
Caffeic acid phenethyl ester; Phenethyl caffeate; 104594-70-9; CAPE; phenethyl 3-(3,4-dihydroxyphenyl)acrylate; Capeee; Phenylethyl caffeate; 115610-29-2; caffeic acid phenylethyl ester; UNII-G960R9S5SK; 2-phenylethyl caffeate; PHENETHYL CAFFEATE (CAPE); Caffeic acid-phenethyl ester; CHEBI:8062; G960R9S5SK; CHEMBL319244; 100981-80-4; Caffeic acid 2-phenylethyl ester; SWUARLUWKZWEBQ-VQHVLOKHSA-N; 2-phenylethyl 3-(3,4-dihydroxyphenyl)-2-propenoate; Caffeic Acid Phenethyl Ester, Synthetic; 2-Phenylethyl (2e)-3-(3,4-Dihydroxyphenyl
Cross-matching ID
PubChem CID
5281787
ChEBI ID
CHEMBL319244
CAS Number
CAS 115610-29-2
TTD Drug ID
D06YGF
INTEDE Drug ID
DR2154

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.45 0.00e+0 127/171 (74.27%) HERPUD1;HSPA1A;DDIT3;...
Steroid biosynthesis 2.17 0.00e+0 19/20 (95%) MSMO1;LIPA;SQLE;...
Folate biosynthesis 2.11 0.00e+0 23/26 (88.46%) AKR1C3;AKR1B10;AKR1B1;...
Ferroptosis 2.09 0.00e+0 36/41 (87.8%) HMOX1;SLC7A11;GCLC;...
Glutathione metabolism 2.09 0.00e+0 43/57 (75.44%) GPX2;GCLC;CHAC1;...
Fructose and mannose metabolism 2.06 0.00e+0 30/33 (90.91%) AKR1B10;AKR1B1;SORD;...
Steroid hormone biosynthesis 1.99 3.38e-3 43/61 (70.49%) AKR1C2;AKR1C3;AKR1C1;...
Protein export 1.98 2.96e-3 17/23 (73.91%) SRPRB;SPCS3;SEC63;...
Cysteine and methionine metabolism 1.95 3.50e-3 43/50 (86%) PSAT1;GCLC;GCLM;...
N-Glycan biosynthesis 1.94 3.15e-3 38/50 (76%) FUT8;STT3A;MGAT2;...
PPAR signaling pathway 1.84 7.88e-3 66/74 (89.19%) SCD;RXRA;PCK2;...
Arginine biosynthesis 1.83 7.23e-3 17/22 (77.27%) GLUD1;ASS1;GLUL;...
Amino sugar and nucleotide sugar metabolism 1.81 8.49e-3 38/48 (79.17%) UGDH;UAP1;PGM1;...
Terpenoid backbone biosynthesis 1.77 1.86e-2 18/22 (81.82%) HMGCR;IDI1;ACAT2;...
Metabolism of xenobiotics by cytochrome P450 1.74 2.31e-2 49/77 (63.64%) AKR1C1;ALDH3A1;CYP1B1;...
Glycine, serine and threonine metabolism 1.72 3.05e-2 31/40 (77.5%) PSAT1;CTH;PSPH;...
Thiamine metabolism 1.72 2.97e-2 12/15 (80%) AK4;AK1
Arachidonic acid metabolism 1.72 2.98e-2 48/61 (78.69%) AKR1C3;GPX2;PLA2G2A;...
Legionellosis 1.70 3.40e-2 51/57 (89.47%) HSPA1A;CXCL8;BNIP3;...
Alanine, aspartate and glutamate metabolism 1.69 3.86e-2 27/37 (72.97%) ASNS;GLUD1;ASS1;...
Fatty acid degradation 1.68 3.75e-2 40/43 (93.02%) ACSL4;ALDH2;ACSL5;...
Starch and sucrose metabolism 1.66 4.30e-2 25/36 (69.44%) GBE1;PGM1;HK2;...
Glycolysis / Gluconeogenesis 1.66 4.49e-2 56/67 (83.58%) ALDH3A1;PCK2;ENO2;...
Nitrogen metabolism 1.66 4.50e-2 16/17 (94.12%) CA12;GLUD1;GLUL;...
Glycerolipid metabolism 1.65 4.32e-2 44/61 (72.13%) AKR1B10;AKR1B1;LPIN2;...
Pentose and glucuronate interconversions 1.65 4.24e-2 17/34 (50%) AKR1B10;UGDH;AKR1B1;...
ABC transporters 1.64 4.73e-2 37/45 (82.22%) ABCB6;DEFB1;ABCC3;...
Selenocompound metabolism 1.63 4.70e-2 11/17 (64.71%) CTH;TXNRD1
Leukocyte transendothelial migration -1.91 3.40e-2 90/114 (78.95%) GNAI2;PIK3CA;CLDN6;...
Tight junction -2.01 4.08e-2 130/169 (76.92%) CLDN6;WAS;RAB8B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 4uM - 20uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 4uM - 20uM 6H, 24H